Anesthesia
Conditions
Brief summary
Randomized controlled clinical Trial to compare the efficacy and duration of postoperative analgesia achieved after adding dexmedetomidine or dexamethasone to bupivacaine in TAP block for lower open abdominal surgeries.
Detailed description
A Comparative study between the use of dexmedetomidine versus dexamethasone as adjuvant to bupivacaine in ultrasound-guided transversus abdominis plane block for post-operative pain relief in patients undergoing lower open abdominal surgeries
Interventions
DRUGDexmedetomidine
adjuvants to 0.25 bupivacaine in TAB block.
Sponsors
Ain Shams University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
20 Years to 60 Years
Healthy volunteers
No
Inclusion criteria
Adult patients, Age 20-60 years. Elective operation under general anesthesia. Physical Status: ASA I and II Patients. Body mass index 25-35 kg/m2.
Exclusion criteria
* Infection at site of injection. * Patient refusal. * Psychiatric or physical illness that lead to inability to cooperate, speak or read. * Abdominal operations under spinal anesthesia. * History or evidence of coagulopathy. * Known allergies to drugs used . * Preexisting neurological disorders.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| 1st time for rescue analgesia | first 24 hours post-operatively | Time to first analgesia requirment(starting from drug injection) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Pain score- Visual Analogue Score (VAS) | First 24 hours post-operatively. | It ranges from 0 indicating no pain till 10 indicating severe intolerable pain with variable degrees of ascending pain in between\] was assessed at 0 min (AT PACU), 2hr,6 hr, 12 hr, 18 hr, and 24 hr postoperatively. |
Countries
Egypt
Outcome results
None listed