Cognitive Function, Stenosis
Conditions
Keywords
Cognitive Function, Intracranial / Carotid Stenosis
Brief summary
Through prospective registration and follow-up, this study will collect data of patients with intracranial/carotid stenosis, including clinical information, neuropsychological scales, multimodal magnetic resonance images. The investigators aim to analyze clinical and imaging characteristics of patients with cognitive impairment related to intracranial/carotid stenosis, in order to achieve early identification of cognitive impairment.
Interventions
DRUGstandard medical treatment
standard medical treatment
PROCEDUREInterventional stenting
Interventional stenting
Sponsors
Second Affiliated Hospital, School of Medicine, Zhejiang University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
40 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patients aged ≥ 40 years * ≥ 50% stenosis in unilateral intracranial / carotid artery * Written informed consent available
Exclusion criteria
* Previous history of major head trauma and any intracranial surgery * Intracranial abnormalities, such as intracerebral hemorrhage, subarachnoid hemorrhage and other space occupying lesions * Extrapyramidal symptoms or mental illness which may affect neuropsychological measurement * Severe loss of vision, hearing, or communicative ability Exit Criteria: * Not meet the inclusion criteria * For any poor adherence, not comply with the requirements of the follow-up, or safety reasons determined by investigator * Any adverse or serious adverse events during the study period judged by investigator
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Changes in the scores of Mini-mental State Examination | 2 years | Total score of 30. Higher scores mean a better outcome. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Changes in cerebral glymphatic function | 2 years | assessed by non-invasive diffusion tensor image analysis along the perivascular space (ALPS-index) |
| Changes in the scores of Montreal Cognitive Assessment | 2 years | Total score of 30 |
| Changes in cerebral blood flow in the territory of the culprit artery | 2 years | — |
| Changes in the scores of Colour Trail Test | 2 years | — |
| Incidence of stroke event including ischemic and hemorrhagic stroke | 2 years | — |
| Changes in the scores of clock drawing test | 2 years | — |
| Changes in the scores of Animal Fluency Test | 2 years | — |
| Changes in the scores of Olfactory stick test | 2 years | — |
| Changes in metabonomics | 2 years | include blood and fecal samples |
| Changes in the scores of Hopkins Verbal Learning Test | 2 years | — |
Countries
China
Contacts
Primary ContactMin Lou, PhD, MD
Outcome results
None listed