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Obstetric Outcomes After Double Embryo Transfer

Obstetric Outcomes After Double Embryo Transfer in Intracytoplasmic Sperm Injection

Status
Completed
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT05322278
Enrollment
927
Registered
2022-04-11
Start date
2022-03-30
Completion date
2024-03-01
Last updated
2024-06-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Double-Embryo Transfer in ICSI

Brief summary

Aim ; to compare obstetric outcomes in relation to number of embryo transfer in ICSI

Detailed description

Assisted reproductive technology with intracytoplasmic sperm injection (ICSI) and IVF is becoming an international direction for couples struggling with infertility. The increasing popularity and frequency of these techniques and the data generated from it has given us a better overview of the efficacy, consequences and costs of these techniques. The aim of assisted reproductive technology (ART) is to achieve pregnancy while decreasing the risk of multiple gestations. When compared with elective single embryo transfer (SET), double embryo transfer (DET) demonstrates a superior pregnancy and live birth rate with a significantly higher risk of multiple gestations. The high frequency of multiple births is the main factor which leads to adverse outcome in IVF/intracytoplasmic sperm injection (ICSI) treatment. Transfer of two embryos does not diminish the chance of a birth when compared with three embryo transfer. How would be the obstetric outcome in pregnancies resulting from DET in IVF/ICSI cycles. Despite achieving a higher pregnancy rates, DET in ART leads to an increase in multiple gestation pregnancies, which are associated with increased both maternal and neonatal morbidity and mortality. Twin pregnancies have a higher incidence of preterm cesarean sections , admissions to the neonatal intensive care unit (NICU), and other maternal complications, when compared with singleton pregnancies. Twin pregnancies have a higher incidence of preterm cesarean sections , admissions to the neonatal intensive care unit (NICU), and other maternal complications, when compared with singleton pregnancies. Most patients prefer to have two embryos transferred, due to financial considerations being the main reason. Studies demonstrate that patients are more likely prefer to choose SET when educated about the risks of multiple gestation pregnancy, but select two embryos for transfer if they have a lower pregnancy rate when compared with transferring one embryo . Cost effectiveness research comparing single versus DET after in vitro fertilization (IVF) has previously been performed, with most studies taking place in areas with mandated IVF insurance coverage, and few incorporating hospital costs linked to obstetrical and neonatal outcomes.

Interventions

OTHERData collection

No interventions

Sponsors

Assiut University
Lead SponsorOTHER

Study design

Observational model
COHORT
Time perspective
RETROSPECTIVE

Eligibility

Sex/Gender
FEMALE
Healthy volunteers
Yes

Inclusion criteria

* all patients subjected with ICSI pregnancy

Exclusion criteria

* incomplete data

Design outcomes

Primary

MeasureTime frameDescription
Live birth1 yearComparison

Secondary

MeasureTime frameDescription
Rate of neonatal morbidities and mortalities in single embryo transfer versus double embryo transfer1 yearComparison
Rate of admission to NICU1 yearComparison
Rate of multiple pregnancies1 yearComparison
Rate of miscarriage1 yearComparison
Rate of PPROM1 yearComparison
Rate of Clinical pregnancy1 yearComparison
Rate of chemical pregnancy1 yearComparison
Rate of preterm1 yearComparison

Countries

Egypt

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026