Cholangiocarcinoma, Liver Fluke-Related Cholangiocarcinoma, Opisthorchiasis
Conditions
Keywords
health education, community-based education, complex intervention
Brief summary
Liver cancer, specifically cholangiocarcinoma (CCA), is very common in different areas in Thailand. Many factors make this cancer more common, such as liver fluke infection, older age, eating raw fish, family history of cancer, alcohol intake, taking certain medicines (praziquantel), low intake of fresh vegetable, and low education. In 2015, researchers from Khon Kaen University developed the Community-based Health Education and Communication (CHEC) program to prevent liver cancer caused by liver flukes in communities of the Khon Kaen province, Thailand. The main aim of this 5-year research study is to enhance the CHEC program to prevent liver cancer, and test if it is effective in improving the knowledge and behaviours of community residents regarding how to prevent liver cancer. This study will take place in Khon Kaen, Thailand. Other aims are to: 1. Increase understanding in the community that make it difficult to prevent liver cancer, as well as community characteristics that can help prevent liver cancer; 2. Incorporate the program we develop in healthcare to prevent liver cancer in Thailand.
Interventions
BEHAVIORALeCHEC program
The eCHEC program is the enhanced Community-based Health Education and Communication (CHEC) model to prevent O. viverrini in an effort to decrease cholangiocarcinoma (CCA) in Khon Kaen, Thailand
Sponsors
Khon Kaen University
Global Alliance for Chronic Diseases (GACD)
Canadian Institutes of Health Research (CIHR)
McMaster University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
20 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* any individual residing in one of the 16 villages selected in the Khon Kaen province of Thailand, aged 20 and older
Exclusion criteria
* any individual 19 years or younger * any individual not residing in one of the 16 pre-selected villages in the Khon Kaen province of Thailand
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Stages of change for risk behaviours affecting the development of CCA. | 12 months | Mean difference in the stages of change for risk behaviours in the intervention group compared to the control group. Self reported, pre- and post- intervention. |
| Intake of fruits and vegetables | 12 months | Mean difference in the self-reported frequency of intake of fruits and vegetables in the intervention group compared to the control group. Self reported, pre- and post- intervention. |
| Smoking | 12 months | Difference in the proportion of smoking habits in the intervention group compared to the control group. Self reported, pre- and post- intervention. |
| Alcoholic beverage intake | 12 months | Mean difference in the intake of alcoholic beverages in the intervention group compared to the control group. Self reported, pre- and post- intervention. |
| Praziquantel use | 12 months | Difference in the proportion of use of the medication praziquantel (prescribed or self-medicated) in the intervention group compared to the control group. Self reported, pre- and post- intervention. |
| Stool test (proportion of stool test concentration) | 12 months | Difference in the proportion of positive stool test of concentration of O. viverrini, pre- and post-intervention. |
| Stool test (mean concentration) | 12 months | Difference in the mean concentration of O. viverrini in the stool test, pre- and post-intervention. |
| Intake of raw fish | 12 months | Mean difference in the self-reported frequency of intake of raw fish in the intervention group compared to the control group. Self reported, pre- and post- intervention. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| BMI | 12 months | Cardiobolic measure linked to developing cancer. Change in the mean body mass index calculated from height and weight (self-reported). |
| Waist circumference | 12 months | Cardiobolic measure linked to developing cancer. Change in the mean waist circumference (measured with measuring tape) |
| Blood pressure | 12 months | Cardiobolic measure linked to developing cancer. Change in the mean measured blood pressure (automated, validated device) |
| Health literacy | 12 months | Mean difference in health literacy knowledge score in the intervention group compared to the control group. Self reported, pre- and post- intervention |
| Quality of life | 12 months | Mean difference in quality of life in the intervention group compared to the control group. Self reported, pre- and post- intervention. Using the EuroQol-5 dimension-5 level (EQ-5D-5L) tool |
| Knowledge of preventative measures against CCA | 12 months | Mean difference in knowledge score about in knowledge of preventative measures against CCA in the intervention group compared to the control group. Measured in questions included in the community survey. |
Countries
Thailand
Contacts
Primary ContactRicardo Angeles, MD, MPH, MHPEd, PhD
Outcome results
None listed