IVF, LOW OVARIAN RESPONSE
Conditions
Brief summary
This study aims to investigate the efficacy of 3 different trigggers used for final maturation in the second ovarian stimulation in double stimulation protocol (aGnRH and hCG-rec vs. aGnRH only vs. hCG-rec only). The main objective is to compare the number of all retrieved oocytes and mature oocytes in patients predicted to be low ovarian responders. This is a controlled randomized clinical study where 165 patients will be recruited.
Interventions
DRUGTriptorelin acetate (a-GnRH)
Adminsitration of triptoreline acetate 0.2 mg for final oocyte maturation in the second ovarian stimuation inthe Double stimulation protocol.
DRUGOvitrelle® (hCG)
Adminsitration of coriogonadotropine alfa 250 mcg for final oocyte maturation in the second ovarian stimuation inthe Double stimulation protocol.
DRUGDecapeptyl 0.1 mg® (a-GnRH) and Ovitrelle® (hCG) used together
Adminsitration of triptoreline acetate 0.2 mg and coriogonadotropine alfa 250 mcg for final oocyte maturation in the second ovarian stimuation inthe Double stimulation protocol.
Sponsors
Instituto Bernabeu
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Age
28 Years to 43 Years
Healthy volunteers
Yes
Inclusion criteria
* BMI below 32 * Presence of both ovaries * Indication for ovarian stimulation under Double Stimulation protocol (Duo Stim) * Meeting the criteria for Duo Stim * Medical history, history and physical examination without alterations * AMH and AFV results in accordnace to Poseidon classification group 3 or 4 no more than 6 months prior to signing the consent form * Ability to participate and comply with the study protocol. * To have given written consent * Normal karyotype and fragile X.
Exclusion criteria
* Non-compliance with instructions and/or non-formalization of consents or legal requirements for IVF. * Concurrent participation in another study
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| number of retrieved oocytes | through study completion, usually will be evaluated on the last day of the treatment | number of oocytes retrieved in the second ovarian stimulation in the double stimulation protocol. |
| number of mature (MII) oocytes | through study completion, usually will be evaluated on the last day of the treatment | number of mature (MII) oocytes retrieved in the second ovarian stimulation in the double stimulation protocol. |
Countries
Spain
Contacts
Primary ContactAnna Pitas, PhD
Outcome results
None listed