Ischemic Stroke
Conditions
Keywords
blood brain barrier, hemorrhagic transformation, ischemic stroke
Brief summary
Hemorrhagic transformation is a common complication of acute ischemic stroke patients . BBB damage is regarded as a major pathophysiological mechanism of hemorrhagic transformation. So, the investigators hypothesis the level of BBB damage biomarker is predictor of intracranial hemorrhage following ischemic stroke.
Detailed description
Hemorrhagic transformation is a common complication of acute ischemic stroke patients . BBB injury often occurs in the early stage of ischemic stroke, leading brain tissue edema or even hemorrhagic transformation with the development of ischemic injury. The biomarker of BBB damage, such as the level of serum occludin, can reflect the extent of BBB injury. So, the investigators hypothesis the level of BBB damage biomarker is predictor of intracranial hemorrhage following ischemic stroke.
Interventions
DIAGNOSTIC_TESTthe level of biomarker in bood
Elisa is used to test the level of biomarker in blood.
Sponsors
Ji Xunming,MD,PhD
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
1. Enrolled patients aged 18-80years. 2. Acute ischemic stroke 3. Informed consent obtained.
Exclusion criteria
1. Tumor stroke or hemorrhagic stroke or hemorrhagic cerebral infarction on admission. 2. Stroke or serious head trauma within the previous 3 months 3. inflammatory or infectious diseases, cancer, coagulation disturbance disease and severe renal and liver failure 4. blood sample occurred hemolysis or cloudy. 5. Incomplete clinical data 6. Platelet count of less than 100,000 per cubic millimeter 7. Received oral anticoagulation therapy preceding the onset of stroke and INR greater than 1.7 or prothrombin times greater than 15 seconds 8. Pregnant or breast-feeding women 9. Patients being enrolled or having been enrolled in other clinical trial -
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| The change of serum biomarkers within 72h in ischemic stroke patients | Day 0, Day 1, Day 2, Day 3. | The level of biomarkers are detected using Elisa(Enzyme Linked Immunosorbent Assay)，biomarkers including Occludin(ng/mL), Claudin-5(ng/mL), MMP-2/9(ng/mL)，c-Fn(ug/mL), ZO-1(pg/mL), vWF(ng/mL), IL-2RA(ng/mL), CCL16(ng/mL), CNTN(ng/mL), SELE(ng/mL) and PGLYRP1(ng/mL). |
Countries
China
Contacts
Primary Contactxunming ji, MD PhD
Backup ContactZhifeng Qi, PhD
Outcome results
None listed