Skip to content

A Setting Focus Overdose Prevention Intervention

A Geospatial Analysis of Hotspots and Targeted Injection Settings Pilot Intervention for HIV Prevention Among People Who Inject Drugs in Baltimore, Maryland

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT05320835
Acronym
Oasis
Enrollment
285
Registered
2022-04-11
Start date
2022-04-30
Completion date
2027-05-30
Last updated
2026-05-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Drug Overdose, HCV, HIV Infections

Brief summary

A pilot injection-setting targeted peer-driven intervention to reduce HIV and hepatitis C virus transmission and overdose risk behaviors among people who inject drugs (PWID).

Detailed description

This is a pilot of an injection setting targeted peer-driven intervention to reduce HIV/HCV transmission and overdose risk behaviors. Participants will be randomized to conditions: 1) Peer education and stocking of semi-public injection settings (SPIS) with risk reduction materials, and the standard of care. Based on their SPIS use, 120 index PWID participants will be selected. A conceptual model for the intervention: The conceptual model is based on social influence, social network, and social cognitive theory. The prior work delineated social influence mechanisms. It is expected that training and modeling of effective communication skills will increase the occurrence of conversations on HIV/HCV and overdose prevention. These conversations will then alter perceived descriptive and prescriptive social norms of risk behaviors. The prior work is being enhanced by increasing the availability of risk reduction materials as well as the cuing and modeling risk reduction behaviors in risk settings. It has been found that PWID are motivated to conduct peer education; it enhances their status and provides them a prosocial role in the community. It is hypothesized that peer outreach and supply of materials to SPIS will lead to reduced sharing of injection equipment and increased naloxone availability.

Interventions

BEHAVIORALHIV, HCV and overdose prevention

HIV, HCV and overdose prevention

Sponsors

Johns Hopkins Bloomberg School of Public Health
Lead SponsorOTHER
National Institute on Drug Abuse (NIDA)
CollaboratorNIH

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
HEALTH_SERVICES_RESEARCH
Masking
SINGLE (Subject)

Masking description

Equal attention

Intervention model description

Randomized Clinical Trial (RCT)

Eligibility

Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes

Inclusion criteria

* Current drug user (opioid use in the prior two weeks)

Exclusion criteria

* Any mental or physical health impairment that impedes ability to participate

Design outcomes

Primary

MeasureTime frameDescription
Overdose prevention6 monthsFrequency of carrying naloxone
HIV/HCV prevention6 monthsFrequency of using used cookers

Secondary

MeasureTime frameDescription
Overdose behaviors6 monthsFrequency of testing drugs before using
Overdose behaviors 26 monthsFrequency of talking about overdose prevention

Countries

United States

Contacts

CONTACTCarl Latkin, PhD
carl.latkin@jhu.edu410-955-3972
CONTACTLauren Dayton, PhD
ldayton2@jhu.edu4105025368
PRINCIPAL_INVESTIGATORCarl Latkin, PhD

Johns Hopkins Bloomberg School of Public Health

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: May 23, 2026