Aging, Alzheimer Disease, Early Onset, Cancer, Chronic Disease, Dementia Alzheimers, Metabolic Disease
Conditions
Keywords
Dampness Syndrome, multi-center study, prospective cohort study
Brief summary
The researchers plain to build a large-scale, longitudinal, prospective cohort characterized by TCM dampness syndrome. With the biobank of this cohort the investigators want to find the causality between TCM dampness syndrome and clinical chronic diseases and a new way to treat clinical disease.
Detailed description
DACOS is a national large- scale, longitudinal, multi-center, prospective, cohort study of natural person aged 35 to 75. The baseline survey and the follow-up surveys will be conducted in 5 areas covering the eastern, northern, western, southern and middle parts of China. In this study 100,000 natural person will be regularly followed up for 5 years(visited once a year), with the loss rate ≤15%. Three parts will be carried in the form of interview, physical examination and biological sample collection. During the interview, the investigators plan to do some questionnaires to learn participants' demographic characteristics, life style, disease history, healthy condition(EQ-5D-5L, SDS,), cognition state(AD-8, MMSE, MoCA) and the results of TCM syndrome differentiation(Score of Dampness syndrome and TCM constitution scale). All biological specimens (including blood, feces, urine, saliva and tongue coating) will be collected and stored in the biological resource center until researchers request their use. With the building up of this cohort, the researchers will analyze the causality between dampness syndrome and specific chronic diseases such as diabetes, coronary heart disease, cancer, dementia and so on.
Interventions
OTHERnatural aging process
To observe the relationship between new cases of diseases and health status of people exposed to different factors such as life style, alcohol consumption, eating habits, etc.
Sponsors
State Key Laboratory of Dampness Syndrome of Chinese Medicine, the Second Affiliated Hospital of Guangzhou University of Chinese Medicine
Guangzhou University of Traditional Chinese Medicine
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
35 Years to 79 Years
Healthy volunteers
Yes
Inclusion criteria
1. Residents aged 30 to 79, whose residence is consistent with their registered permanent residence location; 2. Residents who voluntarily participate in the project, agree to the collection of their biological information, and sign the informed consent form; 3. Residents who have no mental illness and other related diseases, and display a normal ability of expression and understanding;
Exclusion criteria
1. Residents who reject collaboration; 2. Residents who allow no follow-up visits.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| emerging diseases | through study completion, an average of 1 year | This study will pay attention to the emerging situation of clinical chronic diseases, such as cancer, diabetes, hypertension, coronary heart disease, dementia, etc. Each follow-up the researchers will record the incidence of the emerging diseases of interviewees' by questionnaire including the name of the disease, time of onset and treatments. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| European Quality of Life 5-dimensional questionnaire (EQ-5D-5L) | through study completion, an average of 1 year | The EQ-5D comprises five dimensions of health: mobility, ability to self-care, ability to undertake usual activities, pain and discomfort, and anxiety and depression. . EQ-5D-5L, includes five levels of severity for each dimension (no problems, slight problems, moderate problems, severe problems, and extreme problems). The value range 0-100: higher scores mean a worse outcome. |
| Mini-Mental State Exam (MMSE) | through study completion, an average of 1 year | MMSE is a widely used test of cognitive function among the elderly; it includes tests of orientation, attention, memory, language and visual-spatial skills. The value range 0-30: higher scores mean a better Cognitine. |
| interview questionnaire | through study completion, an average of 1 year | Demographic characteristic, life style. disease history, allergies will be involoved. |
| change of the blood routine results | through study completion, an average of 1 year | WBC, RBC, PLT , HB, NEUT% and LYM% will be tested and recorded. Above or below each mormal value will be considered as abnormal. |
| urine routine | through study completion, an average of 1 year | urinary WBC and urinary RBC will be observed. negative or below 5/HP is normal. BLO and GLU and PRO in urine will also be test. Negative is normal. |
| change of faeces routine | through study completion, an average of 1 year | cells in faeces will be tested such as RBC and WBC. Negative occult blood（FOB) is difined normal. |
| change of hepatic function | an average of 1 year | The researchers will check the results of ALT and AST. TBil, DBIL, TBA and TP, ALB. Any indices above or below the criteria range is defined as abnormal. Every time point investigators will record the change of these indices. |
| change of renal function | an average of 1 year | The researchers will check the results of Cr， BUN, TC， LDL， HDL,UA and fasting blood glucose，glycosylanted. Any indices above or below the criteria range is defined as abnormal. Every time point investigators will record the change of these indices. |
| Montreal Cognitive Assessment(MoCA) | through study completion, an average of 1 year | MoCA is a brief, 30-question test that helps healthcare professionals detect cognitive impairments very early on, allowing for faster diagnosis and patient care. MoCA is the most sensitive test available for detecting Alzheimer's disease, measuring executive functions and multiple cognitive domains. The value range 0-30: higher scores mean a better Cognitine. The score above 26 is considered the normal congnitive level |
| change of Hcy | an average of 1 year | change of Hcy |
| change of thyroid function | an average of 1 year | change of TSH ,FT3, FT4 |
| change of Vit B12 and folic acid | an average of 1 year | change of Vit B12 |
| change of coagulation function | an average of 1 year | change of PT, INR,TT,APTT，FIB |
| change of abdominal ultrasound | an average of 1 year | change of abdominal ultrasound |
| change of gynecologic ultrasound | an average of 1 year | change of gynecologic ultrasound |
| change of ECG | an average of 1 year | The researchers will check the change of P, QRS and ST segments separately in electrocardiogram. |
| change of brain MRI | an average of 1 year | change of brain MRI. The investigators will focus on the change of hippocampal volume and the spacing of temporal sulcus gyrus. |
| change of CRP | an average of 1 year | change of CPP |
Countries
China
Contacts
Primary ContactJianwen Guo, MD
Backup ContactBin Zhang, PhD
Outcome results
None listed