Healthy Volunteers, Performance
Conditions
Keywords
Biomechanics, Track cyclists and rowers, Energetics, Muscle, Fatigue
Brief summary
As part of the preparation at the Paris 2024 Olympic Games, the French rowing and cycling federations and a consortium of researchers met to reach an ultimate goal: to increase the number of medals in these two disciplines for Paris 2024 Olympics.
Detailed description
The objective of this study is to evaluate the maximum capacity of power production of athletes by describing their power-endurance profile and the physiological factors underlying this maximum power generation capacity. These assessments will guide coaches and athletes for: 1. the best use of athletes' physical abilities (for race strategy, cycling gear ratio or rowing levers) 2. adaptation of training program to improve the maximum capacity of power production of the athletes, in order to increase the number of medals at the Paris Olympics 2024.
Interventions
OTHERHypoxia
Subjects will be subjected to mild hypoxia simulating an altitude of 1750 m (normobaric hypoxia). Hypoxia decreases oxygen supply to tissue and limit exercise capacity. For this, the subjects will inhale a gas mixture depleted in oxygen (enriched in nitrogen). The barometric pressure at 1500 m being 621 mmHg, PIO2 at this altitude (PIO2 = (621 - 47) x 21%) is 120.5 mmHg. For sea level altitude where the barometric pressure is 760 mmHg, the hypoxic gas mixture should contain (x = 120.5 / (760 - 47)) 16.8% O2. Thus, by inhaling a gas mixture that is oxygen-depleted from 21 to 16.8%, subjects (will simulate the altitude of 1750 and) will experience the equivalent of a 20% reduction in oxygen supply.
Sponsors
Centre Hospitalier Universitaire de Saint Etienne
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
OTHER
Masking
NONE
Intervention model description
This is a prospective multi-center exploratory pilot study of physiology study on athletes, track cyclists or rowers national to international level competitors.
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* experienced, well-trained (national to international level) rowers and cyclists * written consent
Exclusion criteria
* taking medications interfering with measured parameters * contraindication to competitive sport practice * currently participating in an other structured exercise program * muscular, bone or joint injuries * neurologic disease * pregnant
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Maximum force produced at zero speed in a fatigue-free condition | Month : 3 | F0i measurement |
| Speed in a fatigue-free condition | Month : 3 | V0i measurement |
| Maximum force produced at zero speed at the end of the 3 min. | Month : 3 | F0e measurement |
| Speed up produced at the end of the 3 min. | Month : 3 | V0e measurement |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Speed up produced at the end of the 3 min after bicarbonate ingestion | Month : 3 | V0i measurement |
| Maximal oxygen uptake (VO2max) after bicarbonate ingestion | At inclusion | Cardiac stress test |
| Maximal oxygen uptake (VO2max) | At inclusion | Cardiac stress test |
| Maximal Ventilation (VEmax) | At inclusion | Cardiac stress test |
| Cardiac output (QCmax) | At inclusion | Cardiac stress test |
| Maximal cardiac frequency (fcmax) | At inclusion | Cardiac stress test |
| Fibre type determination | Month : 2 | Muscle biopsy of the vastus lateralis |
| Microvasculature analysis | Month : 2 | Muscle biopsy of the vastus lateralis |
| Muscle enzyme activity (Phosphofructokinase (PFK), lactate dehydrogenase (LDH), citrate synthase (CS) et cyclo-oxygenase (COx)) | Month : 2 | Muscle biopsy of the vastus lateralis |
| Maximal voluntary force (N) | Month : 9 | Comparison before and after exercise |
| Speed in a fatigue-free condition after bicarbonate ingestion | Month : 3 | V0i measurement |
| Evoked forces (N) | Month : 9 | Ratio of evoked force at low and high frequencies |
| Maximum force produced at zero speed in a fatigue-free condition after bicarbonate ingestion | Month : 3 | F0i measurement |
| Maximal cardiac frequency (fcmax) after bicarbonate ingestion | At inclusion | Cardiac stress test |
| Fibre type determination after bicarbonate ingestion | Month : 2 | Muscle biopsy of the vastus lateralis |
| Microvasculature analysis after bicarbonate ingestion | Month : 2 | Muscle biopsy of the vastus lateralis |
| Muscle enzyme activity (Phosphofructokinase (PFK), lactate dehydrogenase (LDH), citrate synthase (CS) et cyclo-oxygenase (COx)) after bicarbonate ingestion | Month : 2 | Muscle biopsy of the vastus lateralis |
| Maximal voluntary force (N) after bicarbonate ingestion | Month : 9 | Comparison before and after exercise |
| Rate of force development after bicarbonate ingestion | Month : 9 | Comparison of force development |
| Evoked forces (N) after bicarbonate ingestion | Month : 9 | Ratio of evoked force at low and high frequencies |
| Rate of force development | Month : 9 | Comparison of force development |
| Maximal Ventilation (VEmax) after bicarbonate ingestion | At inclusion | Cardiac stress test |
| Cardiac output (QCmax) after bicarbonate ingestion | At inclusion | Cardiac stress test |
| Maximum force produced at zero speed at the end of the 3 min after bicarbonate ingestion | Month : 3 | F0e measurement |
Countries
France
Outcome results
None listed