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Neural Mobilization for Reduction of Spasticity in Stroke

Effectiveness of Neural Mobilization on Spasticity and Upper Limb Function in Individuals With Stroke

Status
Completed
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT05314465
Enrollment
7
Registered
2022-04-06
Start date
2021-11-22
Completion date
2022-03-15
Last updated
2022-08-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Stroke

Keywords

Stroke, spasticity, neural mobilization, Upper limb

Brief summary

Spasticity after stroke is common that affect upper limb strength and make activities of daily living difficult. There are many techniques but not any standardized technique for long term effect on reduction of spasticity and improving upper limb strength. This study aimed to explore and understand the effectiveness of neural mobilization on reduction of spasticity and improving upper limb strength in individuals with stroke. This is mixed method approach of embedded design, multicentric study recruited 7 individuals with stroke as no new themes or codes were emerging (data saturated). Median nerve mobilization was given 20 oscillations per minute for 3 times & repeated 3 times with a pause of 1 minute between each sets for 5times/week for 4weeks. Outcome measures were Modified Ashworth Scale (MAS), Brunnstrom's grading of hand recovery and Hydraulic hand dynamometer(HHD) for grip and pinch strength. Pre and post outcomes data were collected at baseline and 4weeks after intervention and in depth face to face structured interviews was conducted after 4weeks of intervention to explore the effectiveness of median nerve mobilization on reduction of spasticity and the improvement of upper limb strength.

Detailed description

Spasticity after stroke is common that affect upper limb strength and make activities of daily living difficult. There are many techniques but not any standardized technique for long term effect on reduction of spasticity and improving upper limb strength. This study aimed to explore and understand the effectiveness of neural mobilization on reduction of spasticity and improving upper limb strength in individuals with stroke. This is mixed method approach of embedded design, multicentric study recruited 7 individuals with stroke as no new themes or codes were emerging (data saturated). Median nerve mobilization was given 20 oscillations per minute for 3 times & repeated 3 times with a pause of 1 minute between each sets for 5times/week for 4weeks. Primary outcome measure was Modified Ashworth Scale (MAS) to assess elbow and wrist flexors spasticity and secondary outcome measures were Brunnstrom's stages for hand recovery and Hydraulic hand dynamometer(HHD) to measure grip and pinch strength. Pre and post outcomes data were collected at baseline and 4weeks after intervention and in depth face to face structured interviews was conducted after 4weeks of intervention to explore the effectiveness of median nerve mobilization on reduction of spasticity and the improvement of upper limb strength.

Interventions

Median nerve mobilization was given 20 oscillations per minute for 3 times & repeated 3 times with a pause of 1 minute between each sets for 5times/week for 4weeks.

Sponsors

Asir John Samuel
Lead SponsorOTHER

Study design

Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE

Eligibility

Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No

Inclusion criteria

1. Participants with subacute and chronic stroke (1month and above) having upper limb spasticity. 2. Participants with haemorrhagic and ischemic stroke. 3. Participants who tolerate the supine position. 4. Participants who are oriented and alert. 5. Both males and females. 6. Participants older than 18 years.

Exclusion criteria

1. Participants with a score greater than 3 on The Modified Ashworth Scale. 2. Participants with affected speech. 3. Participants with upper limb deformity. 4. Participants experiencing dizziness. 5. Any increase in the dosage of anti-spastic medications during the intervention period. 6. General health problems or pathologies that affect the nervous system like uncontrolled diabetes, hypertension and recent surgeries. 7. Recent onset of worsening neurological signs.

Design outcomes

Primary

MeasureTime frameDescription
Modified Ashworth Scale (MAS)Change from baseline and 4 weeksFor spasticity, Total 4 grades are there. Grade 0 means no increase in muscle tone and grade 4 means affected part rigid in flexion or extension. More grade means more spasticity is there.

Secondary

MeasureTime frameDescription
Brunnstrom's stages for hand recoveryChange from baseline and 4 weeksTo check recovery of hand functions. Total 7 grades are there. Increase in grade means increase in hand functions.
Hydraulic hand dynamometerChange from baseline and 4 weeksFor grip and pinch strength

Countries

India

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026