Integration of Cryobiopsies for ILD Diagnoses- Experience Based on 250 Biopsy Procedures.

Conditions

Interstitial Lung Disease

Keywords

Cryobiopsy

Brief summary

A retrospective study on safety and Diagnostic yield in using cryobiopsies as a Diagnostic tool in diagnosing patients under investigation for Interstitial lung diseases. This includes a registration of procedural techniques, complications ( pneumthorax, hemorrhage, exacerbation and mortalt), days admitted at the hospital, diagnoses and diagnostic yield.

Georgia Christoforidou, Filipa Bica Simões, Sandra Duval Dræby, Sissel Kronborg-White, Nils Hoyer et al. (10 authors)

BMC Pulmonary Medicine2026-09-03

10.1186/s12890-026-04676-3

Type III and VI Collagen Remodeling Biomarkers Have the Potential to Distinguish Between Idiopathic Pulmonary Fibrosis and Hypersensitivity Pneumonitis

G. Christoforidou, Sandra Duval Dræby, Sissel Kronborg-White, Nils Hoyer, M.A. Karsdal et al. (10 authors)

American Journal of Respiratory and Critical Care Medicine2025-05-01

10.1164/ajrccm.2025.211.abstracts.a2852

Interventions

None listed

Study design

Observational model

CASE_ONLY

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

No

Inclusion criteria

* \>18years of age * suspected of Interstitial lung Disease * cryobiopsies performed.

Exclusion criteria

* FVC below 50% of predicted * DLCO below 35% * Body Mass Index (BMI) above 35 * pulmonary hypertension with a tricuspidal gradient above 40 mmHg * other cardiac or other comorbidities that would increase the risk of complications

Design outcomes

Primary

Measure	Time frame	Description
Pneumothorax	2 weeks	Pneumothorax, hemorrhage, acute exacerbation and death
Hemorrhage	3 days	Hemorrhage during the procedure
Acute exacerbation	100 days	Acute exacerbation after the procedure
Mortality	100 days	Mortality after the procedure

Secondary

Measure	Time frame	Description
Diagnostic yield	1 month	Diagnostic yield is discussed at multidisciplinary team meetings i.e, adequate biopsies (\>50% alveolated biopsies), histologic pattern, kontribution to the diagnosis.

Outcome results