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Impact of Laparoscopic Ovarian Drilling on Ovarian Reserve in Patients With Anovulatory Polycystic Ovarian Syndrome

Impact of Laparoscopic Ovarian Drilling on Ovarian Reserve (Serum Anti-mullerian Hormone Levels - Antral Follicular Count and Ovarian Volume) in Patients With Anovulatory Polycystic Ovarian Syndrome

Status
Completed
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT05311059
Enrollment
50
Registered
2022-04-05
Start date
2018-05-30
Completion date
2020-03-07
Last updated
2024-02-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Polycystic Ovary Syndrome

Brief summary

Pneumoperitoneum is done by insertion of the verress needle at the inferior edge of the umbilicus putting into consideration the following tests: 1. Needle test: Verress needle patency check. 2. Hissing phenomenon: Needle introduced by open valve mechanism. 3. Aspiration test: Placing a drop of water on the opening of the needle and examine its disappearance into the abdomen. 4. Volume test: Changes occurred in the intra abdominal pressure during gas insufflations. Intra abdominal pressure 12-16 mmHg usually suitable for this pelvic surgery. Introduction of the laparoscopic instruments all in its place * Laparoscopic telescope : From the inferior edge of umbilicus through trocar and sleeve which inserted by corkscrew technique then removed to allow the telescope insertion which connected to light source , camera head and color monitor. * 2nd and 3rd punctures were done allowing another two graspers to be inserted usually at a point represent outer 1/3 of the lateral abdominal wall in an imaginary line from umbilicus to iliac bone Puncturing technique : Fixation of one ovary away from intestine by grasping the ovarian ligament with the traumatic grasper which allow good exposure of the ovary and allow drilling . Drilling needle was introduced and connected by monopolar current, held against ovarian surface for 4 seconds using a power of 40 watt, 4 puncture was done in each ovary with putting into consideration that the puncture must be not superficial and it must go deep through the main substance of the ovary. Cooling of the ovary by lactated ringer's solution, finally removal of all instruments under vision after exclusion of any complication .

Detailed description

Pneumoperitoneum is done by insertion of the verress needle at the inferior edge of the umbilicus putting into consideration the following tests: 1. Needle test: Verress needle patency check. 2. Hissing phenomenon: Needle introduced by open valve mechanism. 3. Aspiration test: Placing a drop of water on the opening of the needle and examine its disappearance into the abdomen. 4. Volume test: Changes occurred in the intra abdominal pressure during gas insufflations. Intra abdominal pressure 12-16 mmHg usually suitable for this pelvic surgery. Introduction of the laparoscopic instruments all in its place * Laparoscopic telescope : From the inferior edge of umbilicus through trocar and sleeve which inserted by corkscrew technique then removed to allow the telescope insertion which connected to light source , camera head and color monitor. * 2nd and 3rd punctures were done allowing another two graspers to be inserted usually at a point represent outer 1/3 of the lateral abdominal wall in an imaginary line from umbilicus to iliac bone. Puncturing technique : Fixation of one ovary away from intestine by grasping the ovarian ligament with the traumatic grasper which allow good exposure of the ovary and allow drilling . Drilling needle was introduced and connected by monopolar current, held against ovarian surface for 4 seconds using a power of 40 watt, 4 puncture was done in each ovary with putting into consideration that the puncture must be not superficial and it must go deep through the main substance of the ovary. Cooling of the ovary by lactated ringer's solution, finally removal of all instruments under vision after exclusion of any complication .

Interventions

Drilling needle was introduced and connected by monopolar current, held against ovarian surface for 4 seconds using a power of 40 watt, 4 puncture was done in each ovary with putting into consideration that the puncture must be not superficial and it must go deep through the main substance of the ovary

Sponsors

Cairo University
Lead SponsorOTHER

Study design

Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE

Eligibility

Sex/Gender
FEMALE
Age
18 Years to 35 Years
Healthy volunteers
No

Inclusion criteria

* o Age of woman: 18 - 35 y. * Anovulatory PCO. * Clomiphene citrate resistant Woman: * Full dose of Clomiphene citrate. * 6 Months of ovarian induction. * Normal semen analysis and Hystrosalpingography

Exclusion criteria

* o Age below 18y or above 35. * Ovulatory PCO. * Responder to Clomiphene citrate. * Obvious cause of infertility rather than PCO. * Hyperandrogenism due to any other endocrinal disorder

Design outcomes

Primary

MeasureTime frameDescription
Antral follicular count3 months from laparoscopyAFC is defined as counting of all echo lucent rounded follicles measuring (2-10mm) that present in the substance of the ovary
AntiMullerian hormone3 months from laparoscopyPlasma samples were assayed for AMH in duplicate using a commercial enzyme-linked immunosorbant assay kit.

Countries

Egypt

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026