Cancer Screening, Cervical Cancer, Cervical Cytology, Cervical Intraepithelial Neoplasia, Human Papillomavirus Infection
Conditions
Brief summary
This study is to investigate retrospectively the results of cervical cytology and high-risk human papillomavirus in the past 20 years recorded in Peking Union Medical College Hospital. The histological findings after cervical cancer screening were reviewed. The diagnostic values of different screening strategies were compared based on the results of cervical histology. The primary endpoint is the diagnosis of grade 2 cervical intraepithelial neoplasia (CIN2) or more severe lesions (CIN2+). The secondary endpoints include following objectives: (1) the invasive procedures needed according to the screening results; (2) the diagnosis of vaginal and/or vulval intraepithelial neoplasia; (3) the persistence and recurrence of human papillomavirus infection; and (4) the cost-effectiveness of screening strategies for CIN2+.
Interventions
None listed
Sponsors
Lei Li
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Aged 18 years or older * With definite cervical histology after cervical cancer screening, ore with at least one screening test after first testing
Exclusion criteria
\- Not meeting all of the inclusion criteria
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| CIN2+ | One year | CIN2+ detected by various screening methods |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Invasive procedures | One year | Invasive procedures needed according to the screening results |
| Vaginal intraepithelial neoplasia (VaIN) | One year | VaIN detected by various screening methods |
| Vulval intraepithelial neoplasia (VIN) | One year | VIN detected by various screening methods |
Countries
China
Contacts
Primary ContactLei Li, M.D.
Outcome results
None listed