Epilepsy
Conditions
Brief summary
Prospective interventional study with implantation of micro-electrodes to study the brain networks in epilepsy at high spatiotemporal resolution.
Detailed description
The goal of this trial is to study brain activity in epilepsy at high spatiotemporal resolution. Apart from the epileptogenic network (dysfunctional areas), the investigators will study human brain function. The use of micro-electrode arrays allows to study the human brain a high spatiotemporal resolution, even at the single neuron level. Scientific objectives of the current project: * To record neural signals from macro-electrodes and delineate the epileptogenic network and study brain function during specific tasks. * To record neural signals from micro-electrodes and delineate the epileptogenic network and study brain function during specific tasks. * Identifying pivotal regions for BMI applications and developing online decoding algorithms. * Comparing neural recordings to fMRI activity
Interventions
DEVICEmacro/micro electrode recording
intracranial macro/micro-electrode placement at the cerebral cortex or in deeper brain areas with te use of macro/micro electrode recording. Macro/micro electrodes are placed at the cerebral cortex or in deeper brain areas in order to precisely identify the epileptogenic focus
Sponsors
Universitaire Ziekenhuizen KU Leuven
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 90 Years
Healthy volunteers
No
Inclusion criteria
* Age ≥18 yo * Epilepsy patients undergoing intracranial electrode placement. * Able to understand the procedure involved and to consent.
Exclusion criteria
* Age \< 18 yo * Pregnancy
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Electrophysiological recordings: single neuron recordings | 15 years | The investigators will investigate the epileptogenic network by recording neural activity at different spatiotemporal scales and using different modalities. The investigators will be looking at \* Electrophysiological recordings: \- single neuron recordings (outcome measure: spike rate) |
| Electrophysiological recordings: LFP | 15 years | The investigators will investigate the epileptogenic network by recording neural activity at different spatiotemporal scales and using different modalities. The investigators will be looking at \* Electrophysiological recordings: \- local field potentials (LFP) (outcome measure: mainly power in the beta and gamma band, but also alfa and theta band) |
| fMRI recordings | 15 years | \* fMRI recordings (outcome measure: Blood Oxygen Level Dependent (BOLD) signal increases/decreases) By performing electrophysiological recordings and fMRI recordings in the same subjects, we will be able to compare both modalities with each other. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Neurophysiological study of different brain areas: power gamma band | 15 years | Since electrodes are placed for clinical purposes, the investigators will also use these electrodes to investigate normal neural functions of the human brain: vision, perception and motor. \* Macro-electrodes record local field potentials (LFP). The main outcome measure for visual research is the power in the gamma band. The main outcome measure for motor research is power increase in the beta and gamma band. |
| Neurophysiological study of different brain areas: spike activity | 15 years | \* Micro-electrodes and multi-electrode arrays (Utah-array) record local field potentials (LFP) and spike-activity. The outcome measure for spike activity is spike rate. For the local field potentials, the main outcome measure for visual research is the power in the gamma band. The main outcome measure for motor research is power increase in the beta and gamma band. |
| Neurophysiological study of different brain areas: fMRI | 15 years | The outcome measure is blood oxygen level dependent (BOLD) signal changed in response to visual and/ or motor experiments. |
Countries
Belgium
Contacts
Primary ContactAnaïs Van Hoylandt
Outcome results
None listed