Effect of Remote Ischemic Postcondioning on Glymphatic System in Acute Stroke

Effect of Remote Ischemic Postcondioning on Glymphatic System in Acute Ischemic Stroke

Status

UNKNOWN

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT05305625

Enrollment

Registered

2022-03-31

Start date

2022-05-01

Completion date

2023-05-01

Last updated

2022-03-31

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Stroke

Brief summary

Investigators aimed to investigate the changes of glymphatic function after remote ischemic postcondioning treatment in acute ischemic stroke .

Interventions

PROCEDUREremote ischemic postcondioning

remote ischemic postcondioning twice daily, for three consecutive days，the upper arm of the lighter paralyzed side was pressurized to 200mmHg, pressurized 5min and relaxed for 5 minutes for 4 cycles as a complete remote ischemic postcondioning

DRUGstandard therapy

received standardized treatment

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

SINGLE (Subject)

Eligibility

Sex/Gender

ALL

Age

18 Years to 80 Years

Healthy volunteers

Inclusion criteria

* The patient was 18-80 years old; * The NIHSS score was ≤ 25 and NIHSS \> 5，Glasgow coma score ≥ 8; * The patients were diagnosed as anterior circulation cerebral infarction and could start remote ischemic postcondioning within 24 hours after onset * Normal to random time within 24 hours * Written informed consent signed by patients or their families

Exclusion criteria

* patients receiving thrombolysis or endovascular therapy; * modified Rankin scale (mRS) score ≥ 2 before this attack; * other intracranial lesions, such as cerebral hemorrhage, cerebral venous disease, severe subclavian artery stenosis and other diseases involving the brain; * Arterial blood pressure ≤ 90/60mmHg or ≥ 180/100mmHg after treatment.

Design outcomes

Primary

Measure	Time frame	Description
Changes of glial lymphatic system	from baseline to 3 day	The size of the vascular spaces was assessed by brain magnetic resonance of ischemic postcondioning group and standard therapy group

Secondary

Measure	Time frame	Description
Differential expression pattern of differential proteins	from baseline to 3 day	Differential expression pattern of differential proteins in blood of patients with remote ischemic postcondioning group and standard therapy group

Contacts

Primary ContactYu Lu, MD

Yulumed@163.com0086-18151865060

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026