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Analysis of the Relationship Between the Quantitative Index of Cytokines in the Oral Fluid and Inflammation

Analysis of the Interconnection Between the Quantitative Indicators Cytokines in the Oral Fluid and the Local Inflammatory Process at the Stage of Orthopedic Rehabilitation of Patients With Postoperative Jaw Defects.

Status
UNKNOWN
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT05304689
Enrollment
35
Registered
2022-03-31
Start date
2023-11-30
Completion date
2023-12-31
Last updated
2023-07-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic Inflammation

Keywords

Denture, Removable, Cytokine, Saliva, Jaw

Brief summary

The of study is to increase the effectiveness of orthopedic rehabilitation of patients with postoperative jaw defects using various types of replacement structures, taking into account the clinical and morphofunctional characteristics of oral tissues after surgery.

Detailed description

Formation of three groups of patients Patients with extensive jaw defects after surgery for oncological disease of the middle zone of the face (10 people) Patients with jaw defects after complicated tooth extraction (20 people) Healthy volunteers to determine reference values (5 people) Data on the functional state of the dentoalveolar system in the study groups of patients will be obtained. An assessment will be made of the rate of formation of a postoperative defect in patients with postoperative jaw defects, depending on the design features of the prosthesis. Defects of the jaw will be replaced with orthopedic structures, taking into account the individual characteristics of the state of the marginal part of the defect. Data will be obtained on the rate of adaptation and quality of life in patients using dentures made taking into account the assessment of the state of the marginal part of the defect. Clinical recommendations for dentists will be proposed, which will optimize the process of orthopedic dental treatment, taking into account the state of the marginal part of the defect in patients with postoperative jaw defects.

Interventions

DIAGNOSTIC_TESTtest for quantitative index of interleukins in the oral fluid

collection of oral fluid and determination of the content of cytokines by test systems in patients with postoperative wound

Sponsors

Ryazan State Medical University
Lead SponsorOTHER

Study design

Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE

Intervention model description

two groups of patients

Eligibility

Sex/Gender
ALL
Age
30 Years to No maximum
Healthy volunteers
Yes

Inclusion criteria

* Men or women over 30 years of age. The presence of a postoperative defect of the jaw after surgical interventions.

Exclusion criteria

* Men or women under 30 years of age. Decompensated somatic pathology. Pregnancy or breastfeeding in women. Participation in another study.

Design outcomes

Primary

MeasureTime frameDescription
quantitative analysis of cytokines PG/ml1 yearsampling of oral fluid in the study group of patients

Countries

Russia

Contacts

Primary ContactOlga Guiter, PhD
gos.stam@mail.ru+79106159998
Backup ContactKseniya Inzhuvatova
medvedeva.xeniya2011@yandex.ru+79156154757

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026