Acute Coronary Syndrome, Chronic Kidney Diseases
Conditions
Brief summary
Our study is planning to evaluate patients with chronic kidney disease who come to the emergency department with chest pain. Estimated GFR (cisGFR) with cystatin and estimated GFR (creaGFR) with creatinine will be calculated. Symptoms, ECG and troponin values of patients will be evaluated for diagnosis of acute coronary syndrome
Detailed description
Our study is planning to evaluate patients with chronic kidney disease who come to the emergency department with chest pain. Estimated GFR (cisGFR) with cystatin and estimated GFR (creaGFR) with creatinine will be calculated. Symptoms, ECG and troponin values of patients will be evaluated for diagnosis of acute coronary syndrome and the final diagnosis of AMI will be adjudicated by 2 independent cardiologists.Serial troponin measurements and eGFR values will be proportioned. These values the will be evaluated and compared for patients with acute coronary syndrome(culprit lesion on conventional coronary angiography) and non-ACS ones . With these data we aim to facilitate the diagnosis of acute coronary syndrome,increase the specificity and sensitivity of cardiac troponins for the diagnosis of acute coronary syndrome of patients with chronic kidney disease, increase the utility of high sensitive troponins for patients with chronic kidney disease. Again, with these data, it is aimed to reduce the number of false negative and false positive diagnosis of acute coronary syndrome .
Interventions
PROCEDUREpercutaneous coronary intervention
conventional coronary angiography
Sponsors
Ankara Diskapi Training and Research Hospital
Study design
Observational model
OTHER
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
1. Age over 18, 2. chronic kidney diease having chest pain or equivalent of chest pain (dyspnea, diaphoresis, syncope, nausea, vomiting) -
Exclusion criteria
1. STEMI, 2. age less than 18, 3. missing data, 4. patients referred to or accepted from another medical facility
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| anticipated ACS | time passed until PCI (percutaneous coronary intervention) (pre-intervention) or admission to hospital | The role of cystatin C in diagnosis acute coronary syndrome when used with troponin in patients with chronic renal failure. |
| exclusion of acs | time passed during emergency department visit until discharge avarage of 3-6 hours | exclusion of ACS according to current guidelines |
Countries
Turkey (Türkiye)
Contacts
Primary Contactbedriye müge sönmez, assoc. prof.
Backup Contactelif hamzaçebioğlu, resident
Outcome results
None listed