Quantification and Repeatability of Magnetic Stimulation

Quantification and Repeatability of Responses to Rapid Bilateral Magnetic Stimulation of the Phrenic Nerves

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT05302752

Enrollment

Registered

2022-03-31

Start date

2022-07-13

Completion date

2027-12-01

Last updated

2026-07-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Healthy

Brief summary

In this project the quantification and the repeatability of responses to rapid bilateral magnetic stimulation of the phrenic nerves will be investigated in healthy humans.

Interventions

OTHERMagnetic phrenic nerve stimulation

The intervention consists of bilateral rapid magnetic phrenic nerve stimulation on the neck using different stimulation intensities. On one visit, the effect of increasing chest wall stiffness and respiratory muscle work by adding incrementally small weights to the chest/abdomen will be investigated.

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

BASIC_SCIENCE

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to 39 Years

Healthy volunteers

Yes

Inclusion criteria

* healthy * non-smoking * normal lung function * body mass index: 18.5-29.9 kg/m2 * able to communicate in english * willing to adhere to study rules

Exclusion criteria

* acute illness or chronic conditions of the gastrointestinal tract, and health conditions affecting metabolism, the cardiovascular or the respiratory system, or sleep * intake of medications affecting metabolism, the cardiovascular, the neuromuscular or the respiratory system, or sleep * any metal or electronics inside of the body * presence of cardiac pacemaker, implanted defibrillators or implanted neurostimulators * history of seizures or epilepsy * tatoos on the stimulation sites * previous enrolment in this study * for women: pregnancy, breastfeeding, or intention to become pregnant during the study

Design outcomes

Primary

Measure	Time frame	Description
Diaphragm contractility	Continuously measured from 10 sec before until 10 sec after each stimulation. One stimulation lasts for approx. 1 sec	Transdiaphragmatic pressure changes, i.e. changes in esophageal and gastric pressures, will be measured by a pressure transducer connected to balloon-catheters.

Countries

Switzerland

Contacts

PRINCIPAL_INVESTIGATORChristina M. Spengler, Prof.

ETH Zurich, Exercise Physiology Lab, Institute of Human Movement Sciences and Sport

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Jul 9, 2026