Fatigue, Heat Stress
Conditions
Brief summary
The purpose of this study is to measure fatigue and indicators of acute kidney injury during consecutive days of work in a hot environment.
Interventions
OTHERHot Dry
98°F (36.7°C) and 20% relative humidity environment
Sponsors
State University of New York at Buffalo
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
PREVENTION
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 39 Years
Healthy volunteers
Yes
Inclusion criteria
* Healthy individuals * Regularly completes aerobic exercise at least 60 min per week
Exclusion criteria
* History of cardiovascular, metabolic, respiratory, neural, or renal disease * Hypertensive or tachycardic during the screening visit (Systolic Blood Pressure \> 139 mmHg, Diastolic Blood Pressure \> 89 mmHg, heart rate \> 100 bpm) * Current tobacco or nicotine use or previous regular use within the past 2 years * Current or previous musculoskeletal injury limiting physical activity * Taking medications with known thermoregulatory or cardiovascular effects (e.g., aspirin, beta blockers, diuretics, psychotropics, etc.) * A positive pregnancy test at any point during the study or currently breastfeeding * Study physician discretion based on any other medical condition or medication
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change from baseline in fatigue | Hour 4 | Fatigue will be measured using accelerometry, with the primary variable being jerk, the smoothness or unevenness of movement. |
| Biomarkers of acute kidney injury | Hour 4 | Tissue inhibitor of metalloproteinase 2 (TIMP-2) and insulin-like growth factor binding protein 7 (IGFBP7) are biomarkers that have the potential for early prediction of acute kidney injury. |
Countries
United States
Outcome results
None listed