COVID-19 Pandemic, Delirium, Intensive Care Unit Syndrome
Conditions
Keywords
covid19, Heart function, Lung function, Cognitive function
Brief summary
A follow up study of adult patients who have been treated in the ICU at Mölndal hospital due to Covid19 in the period of 2020 to 2022.
Detailed description
The spread of Covid19 in the population in Sweden from 2019 and onwards posed new and serious strain on our ICU capacity. The disease presented with initially influenza like symptoms and evolved into multiorgan failure. 5% of all patients with verified Covid 19 were in need of critical care and among them the in-hospital mortality rate was 20%. Patients will be followed up with after a minimum of three months after discharge from the ICU with regards to organ function. Examinations within the scope of the study are; * Comprehensive heart investigation including ultrasound * Arterial blood gas and lung function tests including computer tomography of the lungs. * Cognitive function with validated questioners * Standardized test of physical function * A panel of blood samples to assess organ function
Interventions
OTHERFollow up
Comprehensive follow up in dedicated follow up unit
Sponsors
Sahlgrenska University Hospital
Study design
Observational model
CASE_ONLY
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patients treated at the Intensive Care Unit at Mölndals hospital from 2020 to 2022 for Covid19 * More than 3 months passed since ICU discharge * Over 18 years of age at time of inclusion * Swedish resident with Swedish unique personal identification number. * Informed consent
Exclusion criteria
* Under 18 years of age at time of inclusion * Not a Swedish resident * Unwillingness to participate
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Covid 19 antibodies | One year | Antibodies IgG against Covid 19 lab test |
| Cognitive function CDR | One year | Standardized cognitive tests, |
| Cognitive function Montreal Cognitive Assessment | One year | Standardized cognitive tests |
| Cognitive function biochemical markers | One year | blood sampling with NFL, NSE, s-100B, fosfor-tau and APOE |
| Physical function | One year | Standardized aggregate test of physical function, including seat raise test and grip strength measurement with validated instruments |
| Coagulation Status | One year | Blood sampling Fibrinogen, D-Dimer, Antithrombin III and platelets, Aggregate variable to determine overall coagulation status |
| Lung Function oxygen saturation | One year | Respiratory function following Covid19, saturation in SaO2% |
| Lung Function, end tidal Co2 in kPa | One year | Respiratory function following Covid19, end tidal carbon dioxide in kPa, |
| Lung Function, complete arterial and venous blood gas in kPa | One year | Respiratory function with arterial and venous blood gas pO2 and pCO2 in kPa |
| Lung Function spirometry | One year | Respiratory function with spirometry in Volumes in ml related to BMI |
| Lung parenchym status | One year | Ct scan of the lungs, assessed by radiology specialist, assessed for fibrosis, bronchiectasia and residual ground glass abnormalities |
| ECG | One year | 5 lead ECG for the detection av arrythmia |
| Cardiac ultrasound | One year | Cardiac ultrasound including ejection fractions (EF%) |
| Cardiac biomarkers Troponin in ng/L | One year | Cardiac function Blood sampling |
| Cardiac biomarkers NTproBNPin ng/L | One year | Cardiac function Blood sampling |
| Cognitive function MMSE | One year | Standardized cognitive tests |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Return to own home | one year | Are the subjects living in their original housing or equivalent? |
| New need for nursing assistance at home? | one year | Are the subjects in need of in home nursing care |
| Frailty | One year | assessed accordingly to Clinical frailty scale |
| Mental fatigue | One Year | self-assessment questionnaire Mental fatigue scale |
| Return to work | One year | Are the subjects working or at the disposal of the labour market |
Countries
Sweden
Outcome results
None listed