Cornea
Conditions
Keywords
silicone hydrogel contact lens, extended contact lens wear, corneal sensitivity, esthesiometry
Brief summary
Soft contact lens wear reduces the amount of oxygen reaching the eye, which may have an influence on corneal sensitivity. The aim of this study is to measure corneal sensitivity with means of liquid jet esthesiometry at baseline and after 6 days of continuous, extended contact lens wear.
Detailed description
Contact lens wear may have an influence on corneal sensitivity, by three mechanisms: hypoxic, mechanical and inflammatory. Extended silicone hydrogel contact lens wear increases the risk of infections. A change in corneal sensitivity may be considered as an indicator for change in corneal physiology. It is there the aim of this study is to measure corneal sensitivity with means of liquid jet esthesiometry at baseline and after 6 days of continuous, extended contact lens wear.
Interventions
silicone hydrogel contact lens
Sponsors
Daniela Nosch
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
OTHER
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* no contact lens wear three days before first visit * corneal radius between 7.4 and 8.0; if corneal radius \>8.0, corneal diameter must be at least 12 mm; if corneal radius \< 7.4, corneal diameter must be \< 12.0 * OSDI score no higher than 13 points
Exclusion criteria
* systemic disease that may have an influence ocular healtjh * active ocular disease and no history of ocular surgery
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| difference in corneal sensitivity threshold baseline and after 7 days of extended contact lens wear | 7+/-1 days | The difference in corneal sensitivity threshold baseline versus after 7 days of extended contact lens wear will be determined. Corneal sensitivity measurement will take place with the Swiss Liquid Jet Aesthesiometer for Corneal Sensitivity (SLACS) and will be recorded in mbar. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| correlation between corneal sensitvity threshold and subjective symptoms | 7+/-1 days | correlation between corneal sensitvity threshold and subjective symptoms after 7 days of extended contact lens wear: corneal sensitivity threshold will be determinded with the Swiss Liquid Jet Aesthesiometer for Corneal Sensitivity (SLACS) and will be recorded in mbar. Subjective Symptoms will be recorded with the CLEDQ8 questionnaire (specifically designed to assess contact lens comfort) |
Countries
Switzerland
Outcome results
None listed