Magnesium Administration After Cardioplegic Arrest With Del Nido Cardioplegia

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT05298618

Acronym

MGSO

Enrollment

152

Registered

2022-03-28

Start date

2022-01-24

Completion date

2024-02-15

Last updated

2024-05-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Del Nido Cardioplegia

Brief summary

The cardioplegia solution of choice in many pediatric cardiac congenital programs is the del Nido solution. While many cardioplegia solutions provide diastolic arrest, del Nido provides a longer period of time between doses of cardioplegia. Many of the other cardioplegia solutions do not incorporate magnesium into the constituents, but del Nido does. Routine practice at CCHMC is to dose 25 mg/kg magnesium upon removal of the heart cross-clamp to protect against hypomagnesemia and associated arrhythmias. However, with the incorporation of magnesium in the del Nido solution, it may not be necessary to administer magnesium post cross-clamp and it could in fact be detrimental if the magnesium level is too high. This observational study will examine the magnesium levels prior to and after cross-clamp removal under our current process. The magnesium levels measured after the administration of del Nido cardioplegia and prior to cross-clamp removal will help inform our current practice.

Interventions

None listed

Study design

Observational model

CASE_ONLY

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Inclusion criteria

* Patients undergoing cardiac surgery requiring CPB and cardioplegic arrest with del Nido cardioplegia solution. * Patients planned to receive post cross-clamp dose of 25 mg/kg magnesium sulfate.

Design outcomes

Primary

Measure	Time frame	Description
Examine magnesium levels prior to and after cross-clamp.	24 months from start of enrollment.	The primary objective of this study is to examine magnesium levels prior to and after cross-clamp.

Countries

United States

Outcome results