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The Effect of Working at Home to Reduce Risk of Respiratory Infection

The Effect of Working at Home Versus at the Office on Risk of Transmission of SARS-CoV-2 and Other Respiratory Agents. A Randomized Controlled Trial

Status
UNKNOWN
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT05298488
Enrollment
2000
Registered
2022-03-28
Start date
2022-03-14
Completion date
2023-09-30
Last updated
2022-03-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

COVID-19, Respiratory Tract Infections

Keywords

COVID-19, Infection control, Office from home, Social distancing

Brief summary

The researchers will recruit volunteers from various organisations who are willing and able to be randomised to either working from home for 4 weeks followed by working in the office for 4 weeks, or vice versa. The goal is to assess whether working from home has an impact on the risk of symptoms of respiratory infection.

Detailed description

Working in the office entails to various extent contact with colleagues, and for some it includes close contact to others when using public transport to and from work. This likely increases the risk of transmission and many workplaces along with health authorities have strongly advised employees to work from home as much as possible during the COVID-19 pandemic. On the other hand, most people are infected from other family members, and working from home increases exposure to other family members. There are few, if any trials on the effects of teleworking/home office on the risk of transmission of SARS-CoV-2 and other respiratory agents. Studies that have looked at associations between teleworking and COVID-19 have found a negative correlation. A systematic review from the National Institute of Occupational Health (STAMI) showed that workers working from home experienced higher work satisfaction and productivity, while also reporting negative effects on work-life balance, professional isolation and working outside core hours. Effects on health outcomes were mixed. The quality of the studies was generally judged as low. However, working at the office could mean increased exposure to transmission of SARS-CoV-2 and other respiratory agents. Thus, both interventions do pose potential benefits and harms for the participants. Working from home is a broadly applied intervention nationally and internationally during the COVID-19 pandemic. Establishing what effect this intervention has on actual spread of SARS-CoV-2 and other respiratory agents could hence provide valuable insight to national and local authorities and decision-makers. The researchers propose to conduct a trial to assess whether working at home impacts on employees' risk of respiratory infection and reduce the risk of work-related outbreaks. The aim is to reject the null hypothesis that working at home does not reduce the risk of respiratory infections or outbreaks among employees. The researchers plan to conduct the trial as a two-arm multi-period crossover superiority trial where the employees are allocated into two equally sized groups. If this eases the recruitment of firms, the cross-over structure will be dropped. The first and second arm will cross-over (change treatment) after four weeks. Week 1 and week 5 will be considered run-in periods for these arms, and the data collected these run-in weeks will not be used as outcome data in the statistical analysis. The plan is to recruit 3-5 large firms with over 2000 eligible participants. Firms located in Oslo and neighbouring municipalities will be included. These are the areas That are seeing the highest incidence rates of SARS-CoV-2 in the ongoing covid-19 pandemic in Norway. All consenting employees in the selected organizations are eligible to participate in the trial. The organizations can define in advance certain key personnel that cannot take part in the trial. The investigators will compare the following interventions: 1. Participants will strive to be working from home every day. Participants can go to the office in order to complete tasks that cannot be completed from home. 2. Participants will be working from the office most days, but at least three days a week.

Interventions

BEHAVIORALHome office

Working from home

BEHAVIORALOffice

Working at the office

Sponsors

The National Institute of Occupational Health, Norway
CollaboratorUNKNOWN
Norwegian Institute of Public Health
Lead SponsorOTHER_GOV

Study design

Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
PREVENTION
Masking
NONE

Intervention model description

The participants will be allocated to either office from home for the first four weeks, followed by working at the office for four weeks, or vice versa.

Eligibility

Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes

Inclusion criteria

* Over 18 years old * Employee in a company/organisation that has agreed to let their employees take part * Willing and able to work form home for 4 weeks (most of the time) Exclusion crieria: \- Unable to work from home

Design outcomes

Primary

MeasureTime frameDescription
Respiratory infection8 weeksThe proportion of participants who report having had symptoms of respiratory disease

Secondary

MeasureTime frameDescription
COVID-198 weeksProportion of participants who test positive for SARS-CoV-2 (based on both self-reported and registry data)
Absenteeism8 weeksNumber of days of absence from work.
Secondary cases of respiratory infection8 weeksNumber of secondary cases (transmission from participants in the study) or outbreaks (2 or more cases)
Work-satisfaction8 weeksSelf-reported work-satisfaction (Question: To what extent were you able to carry out your work in a good way during the last week? 5-unit ordinal scale from Very little to Very much).
Work-life balance.8 weeksPerceived work-life balance (Question: To what extent has your work been at the expense of your own or other family members' free time?) Ordinal 5-unit scale from Very little to Very much.

Countries

Norway

Contacts

Primary ContactPetter Elstrom, PhD
petter.elstrom@fhi.no+47 91149202
Backup ContactAtle Fretheim, PhD
atle.fretheim@fhi.no

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026