Hypoxia
Conditions
Keywords
high flow nasal oxygenation, hypoxemia, bronchoscopy, effective flow
Brief summary
Patients undergoing sedated bronchoscopy were randomized into six groups (10 Liters/minute \[L/min\], 20 L/min, 30 L/min, 40 L/min, 50 L/min, 60 L/min). The primary outcome was the incidence of hypoxemia.
Detailed description
It's a double-blind, randomized trial. The patients'demographic information, such as sex, weight, height, smoking status, present illness and history of past illness, were collected. After successful peripheral intravenous access, all patients, before sedation, received 20 min nebulization with lidocaine via a nebuliser facemask. The basic oxygen saturation, heart rate, and blood pressure of the patients were recorded by the investigators.Patients in the HFNO group received humidified oxygen at different rates via a high-flow nasal cannula (AIRVO2, New Zealand). After sedation with propofol and sufentanil, continuous electrocardiography and pulse oximetry were recorded, and the blood pressure of the patients was monitored throughout the procedure. . After bronchoscopy, patients were transferred to the post anesthesia care unit (PACU) if their vital signs were stable.
Interventions
DEVICEhigh flow nasal cannula
The patients were randomized into 6 groups, each group received different flow of oxygen, to observe the incidence of hypoxemia between different groups.
Sponsors
Zhejiang Cancer Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
* (1) undergoing sedated bronchoscopy * (2) 18 to 70 years of age; * (3) American Society of Anaesthesiologists (ASA) class: I-III
Exclusion criteria
* (1) severe cardiac disease, including aortic stenosis, mitral stenosis, hemodynamic instability caused by severe arrhythmia, and acute myocardial infarction or cardiac surgery within the last 6 months; * (2) severe hypoxemia (SpO2 \< 90% without oxygen supply on admission), caused by interstitial lung disease, end-stage chronic obstructive pulmonary disease (COPD) or other diseases; * (3) upper respiratory tract infection or lung infection; * (4) refusal to participate in this study.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| the incidence of hypoxemia | during bronchoscopy | hypoxemia was defined as SpO2 \< 90% |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| jaw thrust maneuver | during bronchoscopy | percentage of jaw thrust maneuver |
| increase of flow rate | during bronchoscopy | percentage of increase of flow rate |
| bag-mask ventilation | during bronchoscopy | percentage of bag-mask ventilation |
Countries
China
Outcome results
None listed