Oligosaccharide, Sialic Acid
Conditions
Keywords
Infant, Human milk, Growth and development, immune level
Brief summary
A prospective, multicentre, randomized, double-blind, parallel control study was conducted to analyze the changes in growth, intestinal flora, and immune function of infants with different feeding patterns from postnatal to 1 year of age.
Detailed description
Breast milk is the most beneficial and safe natural food for the growth and development of infants, but some mothers cannot complete breast feeding.For infants who cannot be breastfed, how to improve the composition of formula milk powder and improve the growth and development of infants is an important issue to be solved urgently in this field.It has been found that new compound functional ingredients oligosaccharides and sialic acid may be beneficial to the healthy growth and development of infants and young children, but the specific mechanism and significance are still unclear due to the lack of systematic research.Known as the second Brain, the gut is connected to the Brain via the brain-gut-axis.Intestinal microecological status can significantly affect the development of infant nervous system and immune system, and then affect the occurrence of related diseases in adulthood.Oligosaccharides and sialic acid may affect the structure of intestinal microecology, protect the immune function of infants and promote the healthy development of infants.This project is based on the previous studies, using multicenter, prospective, randomized, double-blind, parallel-group trial, discussion of oligosaccharides and sialic acid in infants and young children the intestinal micro ecology and the regulation of immune function and the role mechanism, revealing the oligosaccharides and sialic acid in infants and young children the role of immediate and long-term growth, and the significance of these new type of composite function is added to the dairy ingredients, to research and development more accord with our country new dairy products provide theoretical basis for the healthy growth of infants and young children.
Interventions
DIETARY_SUPPLEMENTThe infants who drank milk powder were given a dietary intervention four months before
The infants who eat milk powder were randomly divided into two groups: group containing new compound functional ingredients and group without new compound functional ingredients
Sponsors
Peking University First Hospital
Peking University People's Hospital
Peking University Third Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Healthy volunteers
Yes
Inclusion criteria
1. Healthy infants; 2. Full-term (gestational age ≥37 weeks); 3. Birth weight 2500-4500g; 4. Mothers have no history of diabetes, hypertension, heart disease, and other diseases during pregnancy; 5. The guardian signed informed consent and voluntarily enrolled into the group and promised to complete systematic follow-up.
Exclusion criteria
1. Hospitalization with cognitive impairment or deformity ≥2 days 2. History of birth asphyxia (Apgar score \< 3) 3. Severe allergy to milk and serious medical conditions such as intracranial hemorrhage, chronic diarrhea, necrotizing colitis, or acute infection 4. The guardian refused to enroll or could not complete the system follow-up.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Growth and development indexes | 12 months | Baby body length, weight, head circumference gain |
| Neurodevelopmental level | 4 months | The Peabody scale was used to assess the level of neural development of infants at 4 months and 6 months |
Countries
China
Contacts
Primary ContactYing T Han
Outcome results
None listed