Juvenile Idiopathic Arthritis, Sarcopenia
Conditions
Brief summary
Juvenile idiopathic arthritis (AJI), is a frequent inflammatory disease in children, characterized by pain, arthritis, and deformities. Chronic inflammation leads to physical inactivity and can be associated with muscle weakness around affected joints, low bone strength, and mass(3). To our knowledge, no study has focused on the prevalence of sarcopenia in JIA and the data on the muscle disorder are lacking. The purpose of the present study is to detect sarcopenia and identify associated factors in children with JIA
Interventions
DIAGNOSTIC_TESTdensitometry/ handgrip dynamometer
all patients will undergo the Dual-energy X-ray absorptiometry (DXA) and the muscle strength assessment using the handgrip dynamometer
Sponsors
University Tunis El Manar
Study design
Observational model
CASE_CONTROL
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
4 Years to 16 Years
Healthy volunteers
Yes
Inclusion criteria
* children with juvenile idiopathic arthritis fulfilling the ILAR criteria
Exclusion criteria
* We excluded patients who have a prosthesis, nutritional problems, inflammatory bowel disease, coeliac disease, temporomandibular involvement, or another chronic disease.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| skeletal muscle mass | 4 months | Dual-energy X-ray absorptiometry (DXA) measures the appendicular lean mass ( the sum of the lean mass of the arms and legs) and adjusted to the body mass index |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| muscle strenght | 5 months | Three consecutive trials will be measured by the handgrip dynamometer between the dominant and non-dominant sides. the highest value will be used and adjusted to the body mass index |
Outcome results
None listed