Intracranial Stimulation Mapping In Epilepsy

Intracranial Stimulation Mapping In Epilepsy -The InStim Study

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT05290610

Enrollment

Registered

2022-03-22

Start date

2022-06-01

Completion date

2027-09-01

Last updated

2026-04-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Epilepsy

Brief summary

This is a single group prospective study to determine the feasibility for generating brain maps that localize cerebral functions and inter-regional information flow in partial epilepsy in adult patients.

Interventions

OTHERFunctional mapping

Intracranial EEG data acquisition, observation and behavioral testing, and intracranial electrical stimulation

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

BASIC_SCIENCE

Masking

NONE

Intervention model description

This is a single group prospective feasibility study on adult epilepsy patients evaluating whether study tasks and workflow are feasible

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Male or female 18 years and older at screening. * Written informed consent is obtained from the participant to comply with the requirements of the study. * Stated willingness to comply with all study procedures and availability for the duration of the study * Currently undergoing clinically indicated intracranial EEG monitoring for planning of epilepsy surgery in the University of Minnesota/MINCEP program.

Exclusion criteria

* Pregnancy ruled out prior to approval for intracranial EG monitoring. * Persons who are rendered temporarily or permanently invulnerable by inability to understand the research due to study complexity, cognitive impairment, or by inability to make independent decisions owing to University of Minnesota or to Fairview health services.

Design outcomes

Primary

Measure	Time frame	Description
The effect of prefrontal direct electrical brain stimulation on cognitive effort	Immediately after stimulation sessions	The change in subjective value of cognitive effort (area under the curve) after direct electrical brain stimulation to different areas of the prefrontal cortex during an effortful task

Countries

United States

Contacts

CONTACTMatthew Maple

maple036@umn.edu612-946-1424

PRINCIPAL_INVESTIGATORAlexander Herman, MD

UMN

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Apr 10, 2026