Propofol or Midazolam for Sedation and Early Extubation Following Coronary Artery Bypass Graft Surgery

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT05290324

Enrollment

Registered

2022-03-22

Start date

2019-02-01

Completion date

2020-02-01

Last updated

2022-03-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Coronary Artery Disease

Keywords

coronary artery bypass graft, midazolam, propofol

Brief summary

Propofol and midazolam are used frequently as sedating agents among patients who undergo coronary artery bypass graft surgery but no study in Pakistan has been done to compare their effectiveness aiming early extubation.

Detailed description

Propofol is an intra lipid and alkali phenol chemically it is unrelated to sedative agents or anaesthetic. Midazolam is a banzodiazepen. Most of its properties are similar to diazepam. It is a common practice to use sedatives to provide comfort and decrease ventilator-asynchrony in critically ill patients that may require prolonged invasive mechanical ventilation. The other reason to employ sedatives is to reduce the anxiety associated with the inaviseve procedures routinely conducted in the ICU.

Interventions

DRUGMidazolam

Midazolam infusion will be given after the surgery as 0.25 mg/kg/min.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

SINGLE (Subject)

Masking description

Open label

Intervention model description

Radomized Controlled Trial

Eligibility

Sex/Gender

ALL

Age

20 Years to 20 Years

Healthy volunteers

Inclusion criteria

* Patients of American Society of Anesthesiologists (ASA) III who were selected for coronary artery bypass graft surgery.

Exclusion criteria

* History of any psychiatric disease. * Using antidepressants * Alcohol abusers * Obese * Pregnant women

Design outcomes

Primary

Measure	Time frame	Description
Duration of post-surgery sedation	Time in minutes calculated from end of surgery to the time of awakening up to 24 hours in both study groups	Duration of post-surgery sedation following cardiac surgery
Time taken to post-surgery extubation	Time taken in minutes from the end of the cardiac surgery to post-surgery extubation up to 1 week duration in both study groups	Time taken from the end of cardiac surgery to post-surgery extubation

Countries

Pakistan

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026