Diabetes
Conditions
Brief summary
Endocrine hormones, not only blood glucose responsive hormones, but also sexual hormones, thyroid hormones, growth hormones and so on, may have response and activites in hypoglycemia. However, the different responses of endocrine hormones to hypoglycemia in patients With diabetes remain unclear.
Detailed description
This study will observe the changes of insulin, C-peptide, glucagon, growth hormone, IGF-1, ACTH, cortisol, thyroid function, sexual hormone in newly diagnosed men with type 2 and type 1 diabetes mellitus using hyperinsulinaemic hypoglycaemic clamp technique
Interventions
DIAGNOSTIC_TESTThe hyperinsulinaemic hypoglycaemic clamp
Glucose will be clamped at 5.0 mmol/L for approximately 30 minutes, and then be lowered to 3.0 mmol/L for 30 minutes
Sponsors
Nanjing First Hospital, Nanjing Medical University
Study design
Observational model
COHORT
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
MALE
Age
18 Years to 50 Years
Healthy volunteers
Yes
Inclusion criteria
\- Patients * newly diagnosed male patients with type 1 or type 2 diabetes (diagnostic criteria of World Health Organization) * aged 18-50 years * has not been treated with any hypoglycemic drugs * HbA1c\>9% Normal subjects: healthy and had no known illness
Exclusion criteria
* patients with insulin allergy. * any history of hypoglycemic agent intake or were presently taking hypoglycemic agents * any abnormality in liver or kidney function on blood and urine investigations * any history of systemic corticosteroid use in 3 months * any recent infections or acute medical events * any other obvious conditions or associated diseases determined by the researcher: such as severe cardiopulmonary diseases, endocrine diseases, neurological diseases, tumors and other diseases, other pancreatic diseases, history of mental diseases.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| endocrine hormone changes | 20 minutes | changes of endocrine hormones during hyperinsulinaemic hypoglycaemic clamps |
Countries
China
Outcome results
None listed