Rosmarinus Officinalis Versus 2.5%Sodium Hypochlorite as Root Canal Irrigants

Effect of Rosmarinus Officinalis Versus 2.5%Sodium Hypochlorite as Root Canal Irrigants on the Intensity of Post-operative Pain and Bacterial Reduction in Asymptomatic Necrotic Mandibular Premolars

Status

UNKNOWN

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT05289843

Enrollment

Registered

2022-03-22

Start date

2022-05-31

Completion date

2023-07-31

Last updated

2022-03-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Necrotic Pulp

Brief summary

To measure the Effect of Rosmarinus Officinalis versus 2.5%Sodium Hypochlorite as Root canal Irrigants on the Intensity of post-operative pain and Bacterial Reduction in asymptomatic necrotic Mandibular premolars.

Interventions

OTHERRosmarinus Officinallis

Root canal Irrigants

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

TRIPLE (Subject, Investigator, Outcomes Assessor)

Masking description

Triple (Participant , Investigator, Outcomes assessor

Eligibility

Sex/Gender

ALL

Age

20 Years to 45 Years

Healthy volunteers

Yes

Inclusion criteria

1. Systematically healthy patient (ASA I and II). 2. Age between 20 and 45 years with no sex predilection 3. Mandibular permanent premolar teeth: * Diagnosed clinically with pulp necrosis. * Absence of spontaneous pain. * Radiographic evidence of root and root canal. * Slight widening in the periodontal membrane space or with periapical radiolucency. * No response to cold pulp tester (ethyl chloride spray) 4. Patients who can understand and interpret Numerical rating scale (NRS). 5. Patients' acceptance to participate in the trial

Exclusion criteria

* 1- Medically compromised patients having significant systemic disorders. (ASA III or IV). 2- History of intolerance to NSAIDS. 3- If analgesics or antibiotics have been administrated by the patient during the past 24 hours preoperatively as it might alter their pain perception. 4- Pregnant women: Avoid radiation exposure, anesthesia, and medication. 5- Teeth with: i. Vital teeth. ii. Double canal mandibular premolar teeth iii. Association with swelling or fistulous tract. iv. Acute peri-apical abscess and swelling: Need special treatment steps which could involve additional visits with incision and drainage. Also, it could influence initiation and progression of postoperative pain. v. Mobility Grade II or III. vi. Pocket depth more than 5mm. vii. Previous root canal therapy. viii. Non-restorable teeth: Hopeless tooth * Immature teeth. * Radiographic evidence of external or internal root resorption vertical root fracture, perforation, calcification.

Design outcomes

Primary

Measure	Time frame	Description
Postoperative pain after root canal treatment.	Up to 48 hours postoperative.	The patient is asked to grade his degree of pain on the Numerical Rating Scale (NRS) chart which is an 11 points scale consisting of numbers from 0 to 10, where zero reading represents no pain , 1-3 readings represent mild pain, 4-6 readings represent moderate pain. 7-10 readings represent severe pain .

Secondary

Measure	Time frame	Description
Intracanal bacterial load change.	First as a base line and after 15 minutes ( End of the chemo-mechanical preparation).	The intracanal bacterial load change is calculated through using colony forming units per milliliter test before and after root canal preparation.

Contacts

Primary ContactAyah Ta El Sayed, M.D.S

ayahtarek94@gmail.com01221902479

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026