Brain Tumor, Cerebrovascular Disease, MRI
Conditions
Keywords
Brain tumor, Cerebrovascular disease, MRI, Ultra high field
Brief summary
This clinical trial studies the use of 7-Tesla (7T)and 3T magnetic resonance imaging (MRI) in detecting brain diseases. 7T MRI has increased detection sensitivity, including more accurate lesion delineation, higher inter-rater agreement. Diagnostic procedures such as 7T MRI may help ultimately improved diagnostic and therapies confidence to inform decision making than standard 3T MRI.
Detailed description
7T MRI increased detection sensitivity, attain superior anatomic resolution, higher spatial and spectral specificity of advanced quantitative techniques, and shorter scan times than 3T MRI. When applied clinically, these benefits translate to increased detection sensitivity, and ultimately improved diagnostic and therapies confidence to inform decision making. This study aim to detect the image characteristics and diagnostic accuracy of brain diseases on 7T MRI.
Interventions
DIAGNOSTIC_TESTMagnetic resonance imaging
Patients recruited will receive Magnetic resonance imaging.
Sponsors
Chinese PLA General Hospital
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
Yes
Inclusion criteria
* Age≥18 and ≤80 * Having brain diseases (eg: brain tumor, cerebrovascular diseases) * Having no contraindications against MRI or intravenous contrast agent administration * Clinically stable
Exclusion criteria
* Age\<18 or \>80 * Pregnancy and other contraindication to MRI scan * Informed consent not obtained
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| the correspondence between brain tumor cells found in the biopsies and region of interest(ROI) signal intension on the 7T MRI scan and 3T MRI scan | within a month after biopsy | Pathological assessment of biopsy material compared with the lesion's contrast-enhancement signal intension to normal brain white mater on 7T MRI and 3T MRI |
| The visibility of white matter tracts on 7T MRI | within a month after biopsy | Visualization of white matter tracts will be done with the use of diffusion tensor imaging (DTI) on 7T MRI and measuring the mean diffusivity (MD) value on Post-processing workstation ,and analysis the correlation between these values and pathological. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| The correlation between the ROI's signal intension on 7T MRI scan and the KPS in 1 month after operation | within a month after biopsy | The correlation analysis between the T1 contrast-enchanced signal intension, Regional cerebral blood flow on 7T MRI (clinical sequence and perfusion) scan and the KPS in 1 month after operation |
| The visibility of white matter tracts on 7T MRI and 3T MRI | Six months after the biopsy | Visualization of white matter tracts will be done with the use of diffusion tensor imaging (DTI) on 7T MRI and 3T MRI. and analysis the difference of the mean diffusivity (MD) value between 7.0T MRI and 3.0T MRI |
Countries
China
Contacts
Primary ContactKun Cheng, M.S.
Outcome results
None listed