Parkinson, Parkinson Disease
Conditions
Keywords
Parkinson's
Brief summary
The purpose of this project is to increase our understanding of the early state and temporal evolution of neuroplastic changes in the cortex and subthalamic nucleus (STN) of people with PD, and the relationship of these changes to the emergence and expression of PD motor and non-motor signs. Neurophysiological biomarkers derived from this work may be important for the early detection and prediction of progression of disease. They can also provide the means to assess the efficacy of interventions designed to prevent or slow disease progression.
Detailed description
This project will use neuroimaging (7T MRI: structural, diffusion and rest-state functional MRI), from Dr. Noam Harel's protocol IRB# STUDY00008096, and non-invasive brain stimulation (TMS: PAS. SAI) techniques to quantify structural and functional changes in brain function. The TMS experiment will use a Magstim Bistimn 2002 transcranial magnetic stimulation (TMS) unit and standard figure-of-eight coil (70 mm diameter) to deliver stimulation on the surface of the scalp. Stimulation will be delivered using either a single pulse or with a paired-pulse protocol (two stimuli, through the same TMS coil at inter-stimulus intervals of 50 or 80 ms). All surface EMG signals will be pre-amplified within the sensor and sent wirelessly via blue-tooth connection to a Delsys data collection system. Quantitative assessments of motor function (gait, gait initiation, reactive balance, bradykinesia, repetitive alternating movements, rigidity, stop-signal reaction time), and neuropsychological function will used to assess behavioral status at baseline and 30-36 months later.
Interventions
DIAGNOSTIC_TESTNeuroimaging
This project will use neuroimaging (7T MRI: structural, diffusion and rest-state functional MRI) and non-invasive brain stimulation (TMS: PAS. SAI) techniques to quantify structural and functional changes in brain function.
DIAGNOSTIC_TESTQuantitative assessments
Quantitative assessments of motor function (gait, gait initiation, reactive balance, bradykinesia, repetitive alternating movements, rigidity, stop-signal reaction time), and neuropsychological function
Sponsors
University of Minnesota
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
21 Years to 75 Years
Healthy volunteers
Yes
Inclusion criteria
Participants with PD * Diagnosis of idiopathic PD, as determined by a movement disorders neurologist in accordance with the PD Society Brain Bank diagnostic criteria * Not receiving levodopa or dopamine agonist to treat PD (at baseline) * Able to ambulate independently without the use of an assistive device (e.g. cane) for 50 meters Healthy Controls * Age- (+/- 3 years) and sex-matched to participants with PD * Able to ambulate independently without the use of an assistive device (e.g. cane) for 50 meters
Exclusion criteria
* Dementia diagnosis and/or a University of California Brief Assessment of Capacity to Consent (UBACC) score and MacCAT-CR score indicating impaired capacity to consent * History of musculoskeletal disorders that significant affect movement of lower or upper limbs as determined at the time of enrollment * History of bipolar disorder, post-traumatic stress disorder or major depressive disorder * Other significant neurological disorders that may affect participation or performance in the study * Implanted DBS or other neurosurgeries to treat PD * Pregnancy Additional
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in volume of Subthalamic Nucleus | Baseline, 30-36 months | The volume of the subthalamic nucleus is assessed using MRI and reported in millimeters cubed (mm\^3). |
| Change in fractional Anisotropy of Subthalamic Nucleus | Baseline, 30-36 months | Fractional anisotropy, measured using MRI, is a unit-less value between zero and one that describes the degree of anisotropy of water diffusion in a specified brain area. Higher values indicate a greater degree of anisotropy, while a score of zero indicates isotropic diffusion. |
| Change in cortico-STN Connectivity | Baseline, 30-36 months | Cortico-Subthalamic nucleus connectivity is measured using MRI and reported as a z score (unitless). |
| Change in paired Associative Stimulation-Motor Evoked Potential (PAS-MEP) | Baseline, 30-36 months | Motor evoked potential is measured as the amplitude of change in target muscle electrical activity following transcranial magnetic stimulation (TMS) and reported in units of millivolts (mV). |
| Change in Mattis Dementia Rating Scale 2 (DRS-2) | Baseline, 30-36 months | The DRS-2 consists of 24 items, rated on a scale from 0 to 6. Item scores are combined into five subscales: attention (8 items), initiation/perseveration (11 items), construction (6 items), conceptualization ( 6 items), and memory (5 items). These five subscale scores are summed to calculate a total score ranging from from 0 to 144 points, with lower scores indicating worse performance due to dementia. |
| Change in Rey Complex Figure and Matrix Reasoning of the Wechsler Adult Intelligence Scale - IV | Baseline, 30-36 months | — |
| Change in Stroop Color Word Test | Baseline, 30-36 months | — |
| Change in Wisconsin Card Sorting Test | Baseline, 30-36 months | — |
| Change in Delis-Kaplan Executive Function System (D-KEFS) Verbal Fluency Subtest | Baseline, 30-36 months | — |
| Change in Brief Visuospatial Memory Test - Revised (BVMT-R) | Baseline, 30-36 months | — |
Countries
United States
Outcome results
None listed