Lipofilling: Optimal Harvesting Techniques for Breast Reconstruction After Mastectomy in Plastic Aesthetic and Reconstructive Surgery

Lipofilling: Optimal Harvesting Techniques for Breast Reconstruction After Mastectomy in Plastic Aesthetic and Reconstructive Surgery - a Pilot Study

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT05286424

Acronym

LipoTech

Enrollment

Registered

2022-03-18

Start date

2021-02-15

Completion date

2022-07-10

Last updated

2022-08-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

The Impact of Adipose Tissue Quality on Fat Graft Retention

Keywords

fat graft, adipose tissue

Brief summary

The primary aim of this project is to standardize the method for lipofilling by identifying the best technique. In this context, the study will investigate the impact of adipose tissue composition and ideal quantity of the injected fat particularly in view of resorption rate. Correlations between adipose tissue composition, amount of transferred fat, already existing subcutaneous fat layer at the grafting site and resorption rate will be made. The punch biopsy and the non-invasive Lipometer measurements to determine the subcutaneous fat layer thickness in the harvesting and grafting region will be performed in 10 female subjects that undergo elective lipofilling. The study was registered on Clinicaltrials.gov after start of recruitment.

Interventions

PROCEDUREfat grafting

Fat will be removed from abdomen or legs, processed and re-injected into grafting sites.

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

BASIC_SCIENCE

Masking

NONE

Eligibility

Sex/Gender

FEMALE

Age

18 Years to 70 Years

Healthy volunteers

Inclusion criteria

* Women, age 18-70 years (limited upwards due to the indication for lipofilling and the amount of possible secondary diseases) * History of BRCA1 and BRCA2 - positive breast cancer with following subcutaneous mastectomy * Planned, elective breast-lipofilling * Thickness of the skin and subcutaneous fat layer of min. 1 cm (detected via sonography) * Currently healthy individual, willing to participate in this study

Exclusion criteria

* Previous surgery at the harvesting site (e.g. caesarian section) * Pregnancy or planned pregnancy * Current or preceded chemotherapy * Preceded radiatio * Unable to fully understand study procedures and to provide informed consent

Design outcomes

Primary

Measure	Time frame	Description
Adipose tissue dependent take rate	12-24 months	Detect an adipose tissue composition-dependent take rate

Countries

Austria

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026