Anti-Bacterial Agents, Periprosthetic Joint Infection
Conditions
Keywords
Periprosthetic joint infection, Second-stage revision, Anti-Bacterial Agents
Brief summary
This is a multicenter prospective cohort study in which patients were evaluated by inclusion and exclusion criteria before phase II revision surgery. Eligible patients will be included in this study after signing the informed consent form. After the second stage revision, according to the patient's symptoms and examination results, the attending physician used a reasonable antibiotic treatment scheme (including intravenous and oral medication). All patients voluntarily participated in the study and signed informed consent. During the treatment period, all prospective patients underwent clinical evaluation at the time points of 1, 3, 6, 12, 18 and 24 months after the start of antibiotic treatment after phase II revision. The infection control rate of patients was evaluated by follow-up at least 2 years after operation, so as to analyze the effect of antibiotic treatment course after two-stage revision of periprosthetic joint infection.
Detailed description
Inclusion criteria： 1. A diagnosis of PJI was made according to MSIS criteria 2. Received spacer implantation and a full course of antibiotic treatment (at least 6 weeks), the patient was clinically determined to have infection control and underwent secondary joint revision. 3. Age ≥18 years old 4. The patient voluntarily participated in the study, and was physically and mentally tolerant to the treatment process and various tests of the study. He has signed an informed consent form and passed the examination of all the hospital ethics committees participating in the study. Exclusion criteria： 1. Follow up data were not available; 2. The investigator judged that the patient no longer met the criteria of the study due to compliance problems. Recruiting time：2021.10 -2023.10.31 Interventions Group：No Sample size：500 Study Population Description: Patients who underwent secondary replantation surgery for prosthetic joint infection at the First Affiliated Hospital of Fujian Medical University and other sub-centers were selected.
Interventions
DRUGAntibiotics treatment
After receiving intravenous antibiotics treatment for 2 weeks, and clinician determines whether to continue with any antibiotics.
Sponsors
First Affiliated Hospital of Fujian Medical University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
\- 1. A diagnosis of PJI was made according to MSIS criteria. 2. Received spacer implantation and a full course of antibiotic treatment (at least 6 weeks), the patient was clinically determined to have infection control and underwent secondary joint revision. 3\. Age ≥18 years old. 4. The patient voluntarily participated in the study, and was physically and mentally tolerant to the treatment process and various tests of the study. He has signed an informed consent form and passed the examination of all the hospital ethics committees participating in the study.
Exclusion criteria
* 1\. Follow-up data not available. 2. Researchers judge that patients no longer meet the standards of the study due to compliance problems
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Clearance rate of infection | 31, December，2026 | Number of subjects with infection cleared/total number of subjects who completed follow-up |
Countries
China
Contacts
Primary ContactFang
Outcome results
None listed