Psoriasis
Conditions
Brief summary
The aim of this study is to determine the standard tissue levels of SP and its receptor in lesional skin of psoriasis patients in both developing and stationary stages before and after excimer light therapy.
Interventions
DEVICEExcimer light
Excimer light sessions
Sponsors
Cairo University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Type of Psoriasis: plaque psoriasis. * Less than 10% surface area.
Exclusion criteria
* Erythrodermic psoriasis * Pustular psoriasis * Topical treatment for psoriasis for the past 2 weeks. * Systemic retinoids in the last 2 years. * Systemic treatments (including any drugs that affect SP level as Aprepitant) in the last 3 months. * Contraindications to excimer light therapy (history of skin malignancy or precancerous conditions like xeroderma pigmentosum or photosensitivity)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Excimer laser efficiency in active and stable psoriasis | through study completion, an average of 6 months | Determine the clinical improvement using Local psoriasis severity index |
| Excimer laser efficiency on neurogenic inflammation | through study completion, an average of 6 months | level of affection of the neurogenic inflammation in psoriasis lesions after using Excimer light therapy. Determine substance P and its receptor levels before and after therapy. |
Countries
Egypt
Outcome results
None listed