Brugada Syndrome
Conditions
Brief summary
The monocentric UZB registry for Brugada registry is intended to collect all data on patients affected by Brugada syndrome at UZ Brussel hospital (UZB).
Detailed description
The monocentric UZB registry for Brugada registry is intended to collect all data on patients affected by Brugada syndrome. These includes: 1. demographical data: age, sex 2. antropometric data: height, weight, BMI 3. clinical data: comorbidities, arrhythmias, PM or ICD implantation, therapy 3\) data on the families: number of family members, sudden death history. 4) data on the genetics 5) data on: ECG, echocardiography, CT scan, MRI of heart, MRI of brain, ECG imaging, 3D electroanatomical mapping and ablation
Interventions
OTHERNo intervention because it is a patient registry
Sponsors
Universitair Ziekenhuis Brussel
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 100 Years
Healthy volunteers
No
Inclusion criteria
* Brugada syndrome diagnosis
Exclusion criteria
* Other diagnosis different from Brugada syndrome
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Ventricular arrhythmias | through study completion, an average of 10 year | Composite of: sudden cardiac death, aborted sudden cardiac death, ventricular fibrillation, sustained ventricular tachycardia, ICD appropriate therapy |
| Atrial fibrillation | through study completion, an average of 10 year | Atrial fibrillation occurrence |
| Death for any cause | through study completion, an average of 10 year | Death for any cause |
| Cardiovascular death | through study completion, an average of 10 year | Death for cardiovascular cause |
| Genetic mutations | Baseline | Genetic mutations (pathogenic and variant of unknown significance) associated with Brugada syndrome. Wide gene panel with next generation sequencing will be used: Roche SeqCap® EZ Human Exome Probes v3.0 for BrS. |
Countries
Belgium
Contacts
Primary ContactCarlo de Asmundis, MD, PhD
Outcome results
None listed