Schizophrenia
Conditions
Keywords
olfaction, reward
Brief summary
This project proposes to conduct the first study of the predictive utility of olfactory hedonic measurement for targeted psychosocial rehabilitation in schizophrenia. The information gathered from the project is of considerable public health relevance, in that, through simple, reliable olfactory assessment, it will provide knowledge about which individuals are most likely to benefit from these psychosocial interventions. Such information is crucial for tailoring existing interventions and developing new approaches to optimize outcomes in schizophrenia.
Interventions
BEHAVIORALCognitive Enhancement Therapy
CET's group-based exercises are delivered for 1.5 hours each week in a group of 6-8 participants led by a clinician and an assistant, for one year. During each of three modules (basic concepts, social cognition, CET applications), the groups focus on acquisition of adult social milestones in perspective-taking, social context appraisal, and other aspects of social cognition, with psychoeducational lectures, homework assignments, and in-group exercises. Weekly supervision sessions for the clinician trainers will include review of how patients respond to the different demands of computer-based training and group-based exercises and guidance about improving engagement in both.
BEHAVIORALSocial Skills Training
The psychosocial component involves weekly skills training classes delivered over one year, with modules including Communicating Effectively, Making and Keeping Friends, Making the Most of Leisure Time, Healthy Living, Using Medications Effectively, and Making the Most of a Health Care Visit (Pratt et al., 2008). Participants attend two sessions each week (normally morning and afternoon of the same day): a 90-minute session focused on a specific skill and a 60-minute session in which the specific skill is used in role-play exercises.
Sponsors
National Institute of Mental Health (NIMH)
Beth Israel Deaconess Medical Center
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Outcomes Assessor)
Intervention model description
Randomized cluster design with 19 service centers assigned to one of the two treatments.
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
1. age 18 to 65; 2. DSM-5 diagnosis of schizophrenia or schizoaffective or schizophreniform disorder
Exclusion criteria
1. the presence of a current organic brain syndrome; 2. a current and severe substance use disorder (DSM-5); 3. intellectual disability (DSM-5)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in Social Adjustment Scale II | Measurement at 0, 6, 12 months | Measure of ability to engage socially in community settings |
| Change in Heinrich Quality of Life Scale | Measurement at 0, 6, 12 months | Measure of quality of life |
| Change in Social Skills Performance Assessment rating scale | Measurement at 0, 6, 12 months | Social skills measure using role plays |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change in NIH Toolbox® for Assessment of Neurological and Behavioral Function (NIH Toolbox) | Measurement at 0, 6, 12 months | Neurocognition |
| Change in Managing Emotions subscale of the Meyer-Salovey-Caruso Emotional Intelligence Test (MSCEIT) | Measurement at 0, 6, 12 months | Social cognition |
Countries
United States
Outcome results
None listed