Frailty
Conditions
Keywords
exercise, frailty, physical function, mental function, aged
Brief summary
This study aimed to determine the ideal parameters of exercise program for frail middle-aged and older adults on physical and mental functions.
Detailed description
Exercise has been suggested as a possible lifestyle intervention for improving physical and cognitive performance. Various training options depending on various physical circumstances will be presented. However, the ideal exercise protocol for frail middle-aged and older adults had the greater benefits remain unknown. In general, 3-6 months of frequent exercise can enhance physical and cognitive outcome. The investigators conduct this multiple arm, prospective study to determine the ideal parameters of exercise program for frail middle-aged and older adults on physical and cognitive functions. This study designed to recruit 200 older adults with frailty. All the older adults will receive exercise training using either elastic band, dumbbells, machines, treadmill, cycling for 6 months. Outcome measures including a systematic evaluation for frail older persons using comprehensive geriatric assessment, as well as the assessments of physical and cognitive functions before and after interventions.
Interventions
DEVICEexercise training
using either elastic band, dumbbells, treadmill, cycling, machines for 6 months
Sponsors
Taipei Veterans General Hospital, Taiwan
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Investigator, Outcomes Assessor)
Intervention model description
a randomized, multi-arm parallel and controlled intervention study.
Eligibility
Sex/Gender
ALL
Age
50 Years to 85 Years
Healthy volunteers
No
Inclusion criteria
* Patients aged above 50 years old with frailty syndrome
Exclusion criteria
* Acute illnesses, such as unstable cardiac dysrhythmia, sepsis, or unstable vital signs * Physical or Cognitive issues that make it difficult for the patients to participate in our program
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change of Barthel index | Up to 6 months | Test function of activities of daily living, range from 0-100, higher values represent a greater outcome. |
| Change of Montreal Cognitive Assessment | Up to 6 months | Test cognition including memory, attention, and language, range from 0-30, higher values represent a greater outcome |
| Change of Geriatric Depression Scale | Up to 6 months | Test depression status, , range from 0-15, higher values represent a worse outcome |
| Change of Lawton Instrumental Activities of Daily Living (IADL) Scale | Up to 6 months | To assesses a person's ability to perform tasks such as using a telephone, doing laundry, and handling finances.y. A summary score ranges from 0 (low function, dependent) to 8 (high function, independent) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change of Digit symbol substitution test | Up to 6 months | Test cognitive function. The test consists of filling as many empty boxes as possible with a symbol matching each number. The score is the number of correct number-symbol matches achieved. |
| Change of Six-minute Walking Test | Up to 6 months | Test physical function. In healthy subjects, the 6-min walk distance ranges from 400 to 700 m. |
| Change of Mini-mental state examination | Up to 6 months | Test cognitive function, range from 0-30, higher values represent a greater outcome |
| Change of Timed Get-up-and-go Test | Up to 6 months | Test for quantifying functional mobility |
| Change of Memory span test | Up to 6 months | an examiner reads a list of random numbers aloud at about the rate of one number per second. At the end, the person being tested is asked to recall the items, in order. |
| Change of Color Trails Test | Up to 6 months | Test cognitive function. Test is scored by how long it takes to complete the test. |
Countries
Taiwan
Contacts
Primary ContactWang-Sheng Lin, MD
Outcome results
None listed