Critical Illness, Pneumonia, Viral
Conditions
Brief summary
aim of this study is to compare between standard dose methyl prednisolone and mega dose methyl prednisolone as regards outcome reflected by mortality rate, percentage of mechanically ventilated patients and icu length of stay of covid 19 patients admitted in intensive care unit.
Detailed description
Retrospective study for comparison between standard dose methyl prednisolone and mega dose methyl prednisolone as regards outcome reflected by mortality rate ,percentage of mechanically ventilated patients and icu length of stay of covid 19 patients admitted in intensive care unit. Previous studies suggested that cytokine release syndrome could be involved in the pathophysiology of critical SARS.COV.2 resulting in death so early suppression of cytokine storm may be lifesaving in critical patients.
Interventions
OTHERobservation for outcome of methylprednisolone dose
no intervention as it is retrospective study for outcome
Sponsors
Ain Shams University
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Inclusion criteria
* All icu admitted covid 19 patients with positive PCR, diagnosed by CT chest and needing oxygen therapy
Exclusion criteria
* Not requiring oxygen therapy * Negative PCR * Uncontrolled blood sugar or DKA * Patients on long term steroids therapy
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| 28 days mortality rate | 1 month | observation for mortality rate in both groups |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| mechanical ventilation and icu length of stay | up to 3 months | observation for percentage of mechanically ventilated patients and length of stay |
Countries
Egypt
Outcome results
None listed