Hydrogen-rich Water and Treatment of Mucositis Caused by Radiation Therapy in Head and Neck Cancer Patients

Hydrogen Rich Water to Mitigate Acute Mucositis During Radiation Therapy

Status

Completed

Phases

Early Phase 1

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT05278260

Enrollment

Registered

2022-03-14

Start date

2022-05-25

Completion date

2024-11-13

Last updated

2025-05-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Mucositis Oral

Keywords

head and neck cancer, radiation therapy, supportive care

Brief summary

This study explores the effects of hydrogen-rich water on alleviating the radiation-induced acute mucositis in head and neck cancer patients

Interventions

DIETARY_SUPPLEMENTHydrogen tablets

Participants will drink up to 1000 ml (34 fl. oz.) of water daily supplemented with a tablet that releases molecular hydrogen, for the duration of the radiation therapy

DIETARY_SUPPLEMENTControl

Participants will drink up to 1000 ml (34 fl. oz.) of water daily supplemented with a tablet that does not release any molecular hydrogen, for the duration of the radiation therapy

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

SUPPORTIVE_CARE

Masking

QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Diagnosis of a biopsy proven head and neck cancer, early or advanced stage, primary or recurrent tumor, * Planning to receive daily fractionated radiotherapy for over 4 weeks' duration * Karnofsky Performance Score (KPS) of at least 70 * Able to describe pain * Able to swallow food and water * Able to sign consent

Exclusion criteria

Design outcomes

Primary

Measure	Time frame
Number of participants who develop grade 3 oropharyngeal mucositis	3 months after completing radiation therapy

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026