Blood Concentration of Tacrolimus Metabolites
Conditions
Keywords
Tacrolimus, metabolites, liver transplantation
Brief summary
The purpose of this study is to evaluate if concentration of tacrolimus metabolites is increased in patients presenting tacrolimus (TAC) side effects.
Detailed description
The study will evaluate whether the blood concentration of TAC metabolites (13-O-desmethyl-tacrolimus, 15-O-desmethyl-tacrolimus and 31-O-desmethyl-tacrolimus), measured between Day1 and Day5 of its introduction, is increased in patients with TAC toxicity. A blood test will be performed daily from Day1 to Day5 for the measurement of TAC concentration and TAC metabolites concentration.
Interventions
None listed
Sponsors
Rennes University Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Adult patients (\> 18 years) of both sexes, * Candidates for liver transplantation or retransplantation, whatever the etiology and severity of the underlying disease, * Not having expressed their opposition to participation in the study
Exclusion criteria
* Associated transplantation of another organ * Contraindications to TAC administration * Delayed introduction of TAC (beyond the 5th postoperative day) whatever the cause.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Comparison of blood concentration of TAC metabolites between patients presenting TAC related side effects or not. | Day 5 |
Countries
France
Contacts
Primary ContactMichel RAYAR, MD-PhD
Outcome results
None listed