Liver Transplant Disorder
Conditions
Brief summary
Postreperfusion syndrome during living liver transplants remains a serious concern for transplant anesthesiologists. This syndrome is responsible for decreases in systemic blood pressure, systemic vascular resistance, and cardiac output and can even lead to cardiac arrest. Delayed graft function and primary graft nonfunction are closely related to postreperfusion syndrome (Therefore, attenuating the syndrome during anesthesia is of great importance.
Interventions
DRUGMannitol
During the anhepatic phase, the patients in the mannitol group (30) will receive 1 g/kg
OTHER0.9% normal saline
the same amount of 0.9% normal saline
Sponsors
Ain Shams University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
DOUBLE (Subject, Caregiver)
Eligibility
Sex/Gender
ALL
Age
16 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* patients with end-stage liver disease who will undergo living donor transplantation.
Exclusion criteria
* Patients with a history of portopulmonary hypertension. * Hepatopulmonary syndrome. * Cirrhotic cardiomyopathy. * Hepatorenal syndrome types 1 and 2.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| mean arterial blood pressure | one hour after reperfusion | postreperfusion mean blood pressure |
Countries
Egypt
Outcome results
None listed