Bowel Preparation May Lead to a Higher Feasibility of Intestinal Infection

Bowel Preparation for Colonoscopy May Lead to a Higher Feasibility of Intestinal Infection: a Clinical and Basic Research

Status

UNKNOWN

Phases

Early Phase 1

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT05277090

Enrollment

Registered

2022-03-14

Start date

2022-03-15

Completion date

2022-03-15

Last updated

2022-03-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Healthy

Brief summary

An adequate bowel preparation is essential for a high quality of colonscopy. Nowdays, polyethyleneglyco is considered the most safe drug for bowel preparation, and is widely used around the world. However, previous study illustrated that bowel preparation by polyethyleneglyco could lead to qualitative changes in the intestinal microbiota both in mice and human. This study is aimed to investigate wether the changes in the intestinal microbiota could lead to a higher rate of intestinal infection.

Interventions

DRUG2L of polyethyleneglycol

2L of polyethyleneglycol

DIETARY_SUPPLEMENTinulin

15g inulin per day

COMBINATION_PRODUCTprobiotic combination product

participants take 2L of polyethyleneglycol, subsequently take 15g probiotics combination product (including Bifidobacterium lactis, Lactobacillus plantarum, inlulin, Vitamin C) per day. The probiotic combination product, named Mei Ri Yi Jun was produced by Wedge Pharmaceuticals.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

PREVENTION

Masking

SINGLE (Investigator)

Eligibility

Sex/Gender

ALL

Age

18 Years to 60 Years

Healthy volunteers

Yes

Inclusion criteria

* patients who agree to participant in the study

Exclusion criteria

* patients who couldn't stand polyethyleneglycol or inulin patients couldn't provide Informed consent patients who are suffering from sever heart disease, pulmonary disease or renal dysfunction.

Design outcomes

Primary

Measure	Time frame	Description
Polyethyleneglycol could lead to changes in the intestinal flora	one year(from 15/3/2022 to 15/3/2023)	People with polyethyleneglycol administration will lead to a decrease of intestinal flora quantity

Secondary

Measure	Time frame	Description
inulin and probiotics could improve the recovery of gut microbiota	one year(from 15/3/2022 to 15/3/2023)	inulin and probiotics will improve the recovery of flora quantity after Polyethyleneglycol administration

Contacts

Primary ContactGuanjun Kou

kouguanjun88@126.com18560086107

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026