Pain Processing in Inflammatory and Non-Inflammatory Chronic Pain Syndromes

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT05277025

Enrollment

150

Registered

2022-03-14

Start date

2022-03-22

Completion date

2027-07-28

Last updated

2026-08-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Fibromyalgia, Rheumatoid Arthritis

Brief summary

Fibromyalgia (FM) is a chronic musculoskeletal pain disorder that afflicts up to 4% of the general population. The evaluation of pain mechanisms in FM has shown predominant central abnormalities and therefore has been designated as nociplastic pain syndrome. Rheumatoid arthritis (RA) is characterized by polyarthritis and pain from inflamed tissues, consistent with nociceptive pain. FM and RA patients may utilize overlapping pain mechanisms resulting in nociceptive and nociplastic pain.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

CROSS_SECTIONAL

Eligibility

Sex/Gender

ALL

Age

18 Years to 70 Years

Healthy volunteers

Yes

Inclusion criteria

* Ages 18-70 * Fulfills the 1990 and 2011 American College of Rheumatology Criteria for FM * Fulfills the 2010 ACR-EULAR classification criteria for RA * Healthy volunteers: No significant pain/fatigue/depression/anxiety.

Exclusion criteria

* Diabetes * Cancer * Advanced liver, kidney or cardiovascular disease * Neuropathic pain

Design outcomes

Primary

Measure	Time frame	Description
Pressure Pain Thresholds	One hour	Using an algometer pressure pain thresholds will be obtained several times at the upper and lower extremities

Countries

United States

Contacts

CONTACTRoland Staud, M.D.

staudr@ufl.edu352-294-8200

CONTACTMelyssa M Godfrey, BS

melyssa.m.g@ufl.edu352-265-8901

PRINCIPAL_INVESTIGATORRoland Staud, M.D.

University of Florida

Outcome results