End Stage Renal Disease on Dialysis
Conditions
Keywords
AQP1, fluid status
Brief summary
It is a cross sectional observational study. It is to investigate whether AQP-1 polymorphism has any impact on fluid status in hemodialysis patients. The long term stable HD patients in the current center will be enrolled to the study after informed consent. Blood samples will be collected for gene-typing. Fluid status including blood pressure, weekly UF and intra-dialysis body weight change will be collected through their clinical records.
Interventions
observational study, no intervention
Sponsors
RenJi Hospital
Study design
Observational model
COHORT
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
18 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
* age 18-70 * ESRD * maintained HD * no target weight change during the last week of entering the study and achieve target weight at the end of HD section * informed consented
Exclusion criteria
* expected survival time less than 3 months
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| The total ultrafiltration volume in mls from hemodialysis for the whole week of the recruitment | up to 12 weeks | The ultrafiltration volume of each HD section of the enrollment week will be recorded. The total ultrafiltration volume of the week is the primary outcome measure. (In most cases, HD patients have three HD sections per week.) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| The total weight gain in kgs of each HD section of the enrollment | up to 12 weeks | The body weight gain of each HD section of the enrollment week will be recorded. The total body weight gain of the week is the secondary outcome measure. (In most cases, HD patients have three HD sections per week.) |
Countries
China
Contacts
Primary ContactZanzhe Yu, PhD
Backup ContactQi Lu, MD
Outcome results
None listed