Liver Diseases
Conditions
Brief summary
This study involves the one-time collection of whole blood or saliva samples for the extraction and storage of DNA for use in ongoing and future ChiLDReN studies.
Detailed description
The purpose of this study is to establish a mechanism to collect a genetic biosample from the participants previously enrolled into clinical research under ChiLDReN-supported protocols (PROBE and BASIC). The samples will be linked to the data previously collected on the participant. Samples will be stored in the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) specimen repository and will be used in ongoing and future Network and Ancillary Studies of ChiLDReN to further address the pathophysiology and outcomes of these liver diseases.
Interventions
None listed
Sponsors
Arbor Research Collaborative for Health
Study design
Observational model
COHORT
Time perspective
OTHER
Eligibility
Sex/Gender
ALL
Age
24 Years to 25 Years
Inclusion criteria
* For Child Participants 1. Previous enrollment in PROBE or BASIC 2. Exited from one of the aforementioned studies. 3. Consent for DNA sample collection obtained during enrollment during enrollment to one of the aforementioned studies but sample not previously collected. 4. Still followed at the clinical site.
Exclusion criteria
<!-- --> 1. Participant is deceased 2. Participant exited from prior study due to violating eligibility criteria 3. Participant cannot be contacted
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Augment a repository of DNA | beginning of study through study completion, an average of 1 year. | The major objective of this protocol is to augment a repository of DNA from participants previously enrolled into clinical research but for whom a DNA biosample was not previously collected. The acquisition and storage of DNA from participants will make available an important resource for future and ongoing studies that may evaluate etiology, pathogenesis, biomarkers, pharmacogenomics, and genetic modifiers of these rare disorders. |
Countries
Canada, United States
Contacts
STUDY_DIRECTOREd Doo, MD
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
STUDY_DIRECTORKatrina Loh, MD
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
PRINCIPAL_INVESTIGATORJohn Magee, MD
University of Michigan
PRINCIPAL_INVESTIGATORLisa Henn, PhD
Arbor Research Collaborative for Health
Outcome results
None listed