Aortic Valve Stenosis
Conditions
Brief summary
Indication for aortic valve replacement (AVR) in aortic stenosis (AS) is currently based on the classical triad of clinical AS symptoms, estimation of AS severity, and cardiac repercussion at rest. However, presence of symptoms in elderly is often subjective and underreported, and cardiac function analysis at rest underestimates the true impact of the chronic afterload increase. This complicates the diagnosis and hampers timely aortic valve replacement therapy with an impact on prognosis and cardiac function recovery. Exercise imaging in AS may reveal underlying cardiac repercussion and symptoms at an earlier stage and therefore impact prognosis and cardiac function recovery after AVR. Therefore the principal objective of this study is to reveal the factors that determine clinical outcome and hemodynamic function recovery after AVR in AS.
Interventions
DIAGNOSTIC_TESTCPET, 6MWT, QOL assessment
Preoperative and postoperative (6 months + 18 months) assessment
Sponsors
Jessa Hospital
Study design
Allocation
NON_RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Every patient above 18 years of age with an echocardiographic established moderate to severe AS * A guideline indication for aortic valve replacement therapy
Exclusion criteria
* Unable to perform exercise testing * Previous aortic valve intervention * More than moderate other valvular disease * Patients refusing participation or unwilling to sign the informed consent
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Outcome defined by the occurrence of a major cardiac event | 18 months | either 1. Death of cardiovascular origin, or 2. Hospitalization for heart failure, or 3. Deterioration of hemodynamic function during an 18 month follow-up period after AVR. |
Countries
Belgium
Contacts
Primary ContactSarah Hoedemakers, MD
Outcome results
None listed