Arthritis, Rheumatoid, Periodontitis
Conditions
Keywords
Periodontitis, Rheumatoid arthritis, Treatment of periodontitis
Brief summary
Periodontitis is an infectious disease defined by bacteria-mediated inflammation of the supporting tissues of the teeth that if left untreated may ultimately lead to the destruction of the attachment apparatus, culminating in tooth loss. Rheumatoid arthritis is a chronic destructive inflammatory disease characterized by autoantibodies and the accumulation and persistence of an inflammatory infiltrate in the synovial membrane that leads to synovitis and the destruction of the joint architecture. The objective of this study was to evaluate the possible beneficial additional value of non-surgical periodontal therapy on systemic markers of inflammation and clinical and serological parameters of rheumatoid arthritis.
Interventions
PROCEDUREImmediate non-surgical periodontal treatment and oral hygiene instructions
Sponsors
University of Pisa
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER
Masking
TRIPLE (Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Subjects affected by rheumatoid arthritis with a stable therapeutic regimen for at least 3 months preceding the study participation * Subjects with at least 15 teeth * Subjects affected by severe generalized periodontitis that had undergone no periodontal treatment in the 6 months preceding the study participation
Exclusion criteria
* Age younger than 18 years * Pregnancy or breastfeeding * Edentulism * Diagnosis of other autoimmune pathologies, liver disease, diabetes, early/juvenile arthritis or syndromes associated with RA
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Disease Activity Score 28 (DAS-28) | 90 days | Variation of DAS-28 90 days after periodontal treatment |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Erythrocyte Sedimentation Rate (ESR) | 90 days | Variation of ESR 90 days after periodontal treatment |
| C-Reactive Protein (CRP) | 90 days | Variation of CRP 90 days after periodontal treatment |
| Interleuchin-6 concentration (IL-6) | 90 days | Variation of IL-6 90 days after periodontal treatment |
| Oral Health Related Quality of Life (OHRQoL) | 90 days | Variation of OHRQoL 90 days after periodontal treatment |
Countries
Italy
Outcome results
None listed