Corneal Edema
Conditions
Brief summary
Prospective, interventional case control study. Sixty-nine eyes were randomized into 3 groups, 23 eyes each : 2groups received intracameral dexamethasone and triamcinolone (TA) respectively, while controls didn't receive any intraoperative steroids. Intracameral steroids at the conclusion of phacoemulsification significantly improved corneal edema and spared corneal endothelium.
Detailed description
Purpose: Investigating the effect of intracameral steroids at the end of phacoemulsification on corneal edema and endothelial count. Methods: Prospective, interventional case control study. Sixty-nine eyes were randomized into 3 groups, 23 eyes each : 2groups received intracameral dexamethasone and triamcinolone (TA) respectively, while controls didn't receive any intraoperative steroids. On the first postoperative day corneal edema in control compared to dexamethasone and TA groups respectively. One month later, the mean increase of corneal thickness in control compared to intracameral dexamethasone and TA groups, respectively. mean endothelial cell loss in control compared to intracameral dexamethasone and TA groups respectively.
Interventions
OTHERControl group
23 eyes that didn't receive any intraoperative steroids
23 eyes each received intracameral dexamethasone at the conclusion of phacoemulsification Received intracameral 0.4 mg in / 0.1 ml dexamethasone (8mg/2ml®; Amriya or Epico) at the end of phacoemulsification.
DRUGTriamcinolone (TA) group
23 eyes each received intracameral triamcinolone (TA) at the conclusion of phacoemulsification Received intracameral 2 mg/0.05 ml triamcinolone (TA) (Kenacort-A®; Bristol-Myers Squibb) at the end of phacoemulsification.
Sponsors
Beni-Suef University
Cairo University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
NONE
Intervention model description
Purpose: Investigating the effect of intracameral steroids at the end of phacoemulsification on corneal edema and endothelial count. Methods: Prospective, interventional case control study. Sixty-nine eyes were randomized into 3 groups, 23 eyes each : 2groups received intracameral dexamethasone and triamcinolone (TA) respectively, while controls didn't receive any intraoperative steroids.
Eligibility
Sex/Gender
ALL
Age
50 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* Cataract grades 2 to 5 nuclear cataract (LOCS III scale) * uneventful phacoemulsification operation
Exclusion criteria
* extremely hard cataract grade 6 nuclear cataract (LOCS III scale) * soft cataract * subluxated lenses or zonular dehiscence * associated ocular pathology such as glaucoma * any signs of uveitis * trauma * retinal detachment * vitrectomized or silicone filled eyes * corneal disease such as Fuch's dystrophy, corneal opacity * previous refractive corneal surgery * Cases that developed ruptured posterior capsule and vitreous loss * those lost to follow up were excluded and randomly replaced by the next chronological patient
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Endothelial cell loss | Three months | Corneal endothelial cell count (cell/ square mm) after phacoemulsification that was compared to preoperative values |
| Corneal edema | First day postoperative | Clinical grade of corneal edema on the first postoperative day |
| Central corneal thickness (CCT) | Three months | Central corneal thickness in microns after phacoemulsification that was compared to preoperative values |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| IOP | Three months | Intraocular pressure in mmHg rise after after phacoemulsification |
Countries
Egypt
Outcome results
None listed