Post-traumatic Stress Disorder
Conditions
Keywords
Emotion, Post-traumatic stress disorder, Affective forecasting, Virtual reality, Autonomic nervous system, Electrodermal activity
Brief summary
Post-traumatic stress disorder (PTSD) is associated with a marked tendency to have exaggerated and persistent negative beliefs and expectations about oneself or the world . Although posttraumatic stress symptoms have been shown to be associated with a tendency to negatively anticipate the future, affective forecasting skills (i.e., the ability to predict one's own emotional reactions in response to a future event) have never been explored in PTSD . The hypothesis that the PTSD is associated with a negative affective forecasting bias, characterized by a tendency to predict more intense emotional responses to future negative events.
Interventions
BEHAVIORALExperimental: group comparison
* Standardized psychiatric interview (Mini International Neuropsychiatric Interview MINI) * State-Trait-Anxiety Inventory (Spielberger, 1993) * Beck Depression Inventory (BDI-II, 1998) * Cognitive Emotional Regulation Questionnaire (Jermann & al., 2006) Participant installation and testing: 2 stages (forecasting on a computer, and exposure in virtual reality) Task / affective forecasting: * Step 1: forecasting about one's own emotional responses regarding pleasant, neutral and unpleasant scenarios * Step 2: experience of the same scenarios in virtual reality
Sponsors
University Hospital, Lille
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 60 Years
Healthy volunteers
No
Inclusion criteria
* Understanding and being able to express themselves in French * Understanding of informed consent and signature of the study participation form * Giving informed, dated and signed consent * Benefiting from health insurance coverage * Normal or corrected visual and auditory acuity to achieve normality * Group 1 : DSM-5 PTSD criteria, assessed using CAPS and PTSD Checklist for DSM-5 (PCL-5, Weathers & al., 2013) * Group 2: PTSD Criteria A only
Exclusion criteria
Refusal of participation after clear and fair information on the study. * Visual or auditory sensory disability to participate in the study. * Personal history of neurological disease or current neurological disease. * Personal history of current psychiatric disorder or psychiatric disorder (excluding PTSD in patients in the experimental group), assessed via the MINI. * Pregnant or breastfeeding women * Consumption of toxic substances other than tobacco and alcohol. * Minors or adults under guardianship, under judicial protection, persons deprived of liberty. * Groups 2 and 3: personal history of psychiatric disorder or current psychiatric disorder and taking psychotropic drugs * Group 1: personal history of psychiatric disorders or current psychiatric disorders other than anxiety, depressive, trauma and stress-related disorders and treatment with psychotropic drugs not stabilized
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| difference of arousal assessments measured using the Self-Assessment Manikin between the prediction and emotional experience phases | During the experimental task (2 hours) | To compare the subjective affective forecasting bias between the PTSD group and the two control groups |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| subjective correlates of the affective forecasting bias associated with PTSD changes in: valence scores. | During the experimental task (2 hours) | valence scores using the Self-Assessment Manikin (Likert-type scale ranging from 1 \[very unpleasant\] to 9 \[very pleasant\]) |
| autonomic correlates of the affective prediction bias associated with PTSD: changes in the skin conductance response and heart rate. | During the experimental task (2 hours) | changes in the skin conductance response and heart rate assessed using a BIOPAC (System, inc). |
| link between PTSD symptomatology and affective forecasting bias | During the experimental task (2 hours) | PTSD symptomatology assessed using the Clinician-Administered PTSD Scale (CAPS-5) and PTSD Checklist for DSM-5 (PCL-5) |
| link and correlation coefficients between biases measured at the neurovegetative (changes in heart rate and skin conductance) and subjective levels (arousal and valence ratings from the Self-Assessment Manikin) in PTSD | During the experimental task (2 hours) | — |
| link and correlation coefficients between affective forecasting bias and emotion regulation skills within each group | During the experimental task (2 hours) | affective forecasting bias and emotion regulation skills, assessed using the Cognitive Emotional Regulation Questionnaire (CERQ) |
| link and correlation coefficients between affective forecasting bias and anxiety and depression | During the experimental task (2 hours) | anxiety and depression, respectively assessed using the State-Trait-Anxiety Inventory (STAI) and the Beck Depression Inventory (BDI-II), within each group |
Countries
France
Outcome results
None listed